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Exercise and RP (AVAMC and Emory)

NCT ID: NCT03381235

Last Updated: 2018-12-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

4 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-02-23

Study Completion Date

2018-11-28

Brief Summary

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The purpose of this study is to look in humans at the relationship between moderate or little exercise and their potential effects on the retina in patients with Retinitis Pigmentosa (RP).

Detailed Description

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Human studies have shown that regular exercise may have positive effects on common degenerative diseases such as Alzheimer's disease. Exercise has also shown to improve conditions the eye such as macular degenerations, glaucoma, and cataracts. Mice with retinal degeneration which were exposed to exercise showed that it helped to slow the rate of degeneration. The purpose of this study is to look in humans at the relationship between moderate or little exercise and their potential effects on the retina in patients with Retinitis Pigmentosa (RP).

Conditions

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Retinitis Pigmentosa

Keywords

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Exercise Quality of life Progression of disease Retinitis

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Moderate exercise

Subjects in the moderate exercise group will participate in Spin exercise designed by Dr. Nocera.

Group Type EXPERIMENTAL

Spin exercise

Intervention Type OTHER

Each exercise class will consist of 20 minutes of progressive, interval based Spin exercise 2 times a week for 6 months on stationary exercise cycles and will be led by a qualified instructor. The Duration of each session is lengthened based on the progression of the participant and the recommendation of the instructor by 1-2 minutes as needed to a maximum time of 60 minutes per session. Exercise intensity will begin at low levels (50% of maximal heart rate reserve (HRR) and increase by 5% every week (if deemed necessary by the instructor) to a maximum of 75% maximal HRR.

Mild exercise

Sessions will be focused on balance and stretching.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Spin exercise

Each exercise class will consist of 20 minutes of progressive, interval based Spin exercise 2 times a week for 6 months on stationary exercise cycles and will be led by a qualified instructor. The Duration of each session is lengthened based on the progression of the participant and the recommendation of the instructor by 1-2 minutes as needed to a maximum time of 60 minutes per session. Exercise intensity will begin at low levels (50% of maximal heart rate reserve (HRR) and increase by 5% every week (if deemed necessary by the instructor) to a maximum of 75% maximal HRR.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Visual field no less than 10 degrees;
* VA no worse than 20/200 in the better seeing eye.

Exclusion Criteria

* Not able to tolerate exercise due to an underlying medical condition.
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Emory University

OTHER

Sponsor Role lead

Responsible Party

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Jiong Yan

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jiong Yan, MD

Role: PRINCIPAL_INVESTIGATOR

Emory University

Locations

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Emory Clinic, Atlanta VA Medical Center

Atlanta, Georgia, United States

Site Status

Countries

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United States

Other Identifiers

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IRB00093690

Identifier Type: -

Identifier Source: org_study_id