Bridging Animal and Human Models of Exercise-induced Visual Rehabilitation
NCT ID: NCT02911805
Last Updated: 2025-12-05
Study Results
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View full resultsBasic Information
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ACTIVE_NOT_RECRUITING
NA
14 participants
INTERVENTIONAL
2015-06-10
2028-01-28
Brief Summary
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Detailed Description
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Though human and animal studies show that aerobic exercise is beneficial to specific central and peripheral nervous system functions, effects on the retina and vision were unknown until the investigators recently discovered that treadmill exercise directly protects retinal neurons in mice undergoing light-induced retinal degeneration (LIRD). The investigators found that exercise increased levels of brain-derived neurotrophic factor (BDNF) a blood protein in the blood, brain and eyes, whereas treatment of mice with a BDNF inhibitor prevented the protective effects of exercise.
For this study, the investigators will assess visual outcomes and serum biomarkers (e.g, BDNF) in 60 subjects age 18-89 before, during, and after aerobic exercise. Subjects currently enrolled in a 12-week study (under Institutional Review Board (IRB) 56726) examining the effects of aerobic exercise on cognition will have visual testing (ERG, visual acuity, contrast sensitivity, and OCT) and blood collection prior to, during and after the standardized 12-week aerobic exercise regimen to determine whether circulating biomarker levels and visual outcomes are correlated and whether biomarker levels are altered as predicted in animal studies.
This study will determine whether biomarker changes predict sight-saving benefits of exercise. As opposed to surgery or pharmacological treatments, exercise programs provide a means for Veterans to exert some control over their visual disease progression and will increase their overall health.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
SINGLE
Study Groups
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Aerobic Exercise
Exercise 3 times a week
Aerobic exercise
Stationary bicycle ergometer @ 50-80% of maximal heart rate reserve for 20 minutes to 45 minutes
Balance Training
Group balance training 3 times a week
Balance exercise
Instructor-led exercises done in a group setting for strengthening, balance, flexibility
Interventions
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Aerobic exercise
Stationary bicycle ergometer @ 50-80% of maximal heart rate reserve for 20 minutes to 45 minutes
Balance exercise
Instructor-led exercises done in a group setting for strengthening, balance, flexibility
Eligibility Criteria
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Inclusion Criteria
* Aged 18 to 89
* Sedentary as defined by \< 120 min/week of aerobic exercise over prior 3 months
* Non-demented (MMSE 24)
Exclusion Criteria
* Cognitive-executive function deficit (MoCA \< 26)
18 Years
89 Years
ALL
Yes
Sponsors
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VA Office of Research and Development
FED
Responsible Party
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Principal Investigators
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Jeffrey H. Boatright, PhD
Role: PRINCIPAL_INVESTIGATOR
Atlanta VA Medical and Rehab Center, Decatur, GA
Locations
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Atlanta VA Medical and Rehab Center, Decatur, GA
Decatur, Georgia, United States
Countries
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Provided Documents
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Document Type: Study Protocol and Statistical Analysis Plan
Document Type: Informed Consent Form
Other Identifiers
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C1924-P
Identifier Type: -
Identifier Source: org_study_id
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