Study of Sensorimotor Compatibility Effects in Bipolar Affective Disorder.

NCT ID: NCT03249857

Last Updated: 2020-01-09

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 30 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2017-10-26
• Study Completion Date: 2018-08-21

Brief Summary

Based in an embodied approach of cognition, several studies have highlighted a direct link between perception of an object or an emotion and the associated motor responses. This study investigated in patients suffering from bipolar affective disorders whether the perception of emotional words involves an automatic sensorimotor simulation of approach and avoidance behaviors, and whether the perception of an object involves an automatic sensorimotor simulation of object prehension (affordance). We hypothesize that, in this pathology, low level (sensorimotor) cognitive processes are preserved whereas high-level (attentional) are altered. 20 patients suffering from bipolar affective disorders and 20 healthy controls will be recruited. The main objective is the emergence of sensorimotor compatibility effects in approach-avoidance task with emotional stimuli (gain between compatible vs incompatible conditions).

Conditions

Bipolar Affective Disorder

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

patients

Patients suffering bipolar affective disorders and who will perform cognitive tasks + IQ + MINI + experimental task

Group Type: EXPERIMENTAL

cognitive tasks + IQ + MINI

Intervention Type: BEHAVIORAL

Patients will perform different tasks:

• cognitive tasks : reaction time (Alert TEA, Zimmermann and Fimm, 2005) + Edinburgh laterality questionnaire (Oldfield,1971) + hamilton and young's scale (Tohen et al., 2009) + Montreal Cognitive Assessment (MoCA) (Nasreddine et al., 2005) + experimental task (approach/ avoidance and affordance task).
• Intelligence Quotient (IQ) test (PM38, Raven, 1960)
• Mini International Neuropsychiatric Interview (MINI, Van Vliet et al., 2006)

control group

Healthy volunteers (Control group) who will perform cognitive tasks + experimental task

Group Type: ACTIVE_COMPARATOR

cognitive tasks

Intervention Type: BEHAVIORAL

Healthy volunteers will perform only the cognitive tasks = reaction time alert TEA, Zimmermann and Fimm, 2005 + Edinburgh laterality questionnaire (Oldfield, 1971) + experimental task (approach/ avoidance and affordance task).

Interventions

cognitive tasks + IQ + MINI

Patients will perform different tasks:

• cognitive tasks : reaction time (Alert TEA, Zimmermann and Fimm, 2005) + Edinburgh laterality questionnaire (Oldfield,1971) + hamilton and young's scale (Tohen et al., 2009) + Montreal Cognitive Assessment (MoCA) (Nasreddine et al., 2005) + experimental task (approach/ avoidance and affordance task).
• Intelligence Quotient (IQ) test (PM38, Raven, 1960)
• Mini International Neuropsychiatric Interview (MINI, Van Vliet et al., 2006)

Intervention Type: BEHAVIORAL

cognitive tasks

Healthy volunteers will perform only the cognitive tasks = reaction time alert TEA, Zimmermann and Fimm, 2005 + Edinburgh laterality questionnaire (Oldfield, 1971) + experimental task (approach/ avoidance and affordance task).

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

For patients:

• Affiliated or entitled to a social security
• Aged between 18 and 55
• Patients of both sexes suffering from bipolar disorders (DSM V criteria) whatever the subtype
• Stabilized from a point of view clinical and therapeutic
• Euthymic (score <7 at the Hamilton scale, and score <8 at Young's scale)
• Must have given their informed consent before their participation in the study
• Be right-handed (score> 14 on the laterality scale)

For control group:

• Affiliated or entitled to a social security
• Must have given their informed consent before their participation in the study
• Be right-handed (score> 14 on the lateral scale)
• Aged 18 to 55 matched by age (± 5 years), sex, and on the study level of patients (years of schooling after primary school ± 2 years)

Exclusion Criteria

For patients:

• Thymic acute decompensation
• Hamilton scale > 8, Young's scale > 9
• Montreal Cognitive Assessment (MOCA) <26
• History neurological pathology with cerebral impairment or serious somatic disease
• Disorders related to the use of a psychoactive substance, as defined by the DSM-V (abuse, dependence or withdrawal) within 6 months.
• IQ < 70
• History of head trauma

For control group:

• History of head trauma
• Neurological pathology with cerebral impairment or serious somatic disease
• Psychotropic treatment
• Disorders related to the use of a psychoactive substance, as defined by the DSM-V (abuse, dependence or withdrawal)
• IQ < 70

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 55 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Centre Hospitalier Universitaire de Saint Etienne

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Catherine MASSOUBRE, MD PhD

Role: PRINCIPAL_INVESTIGATOR

CHU SAINT-ETIENNE

Locations

Chu Saint-Etienne

Saint-Etienne, , France

Countries

France

Other Identifiers

2017-A00917-46

Identifier Type: OTHER

Identifier Source: secondary_id

1708056

Identifier Type: -

Identifier Source: org_study_id