Emotional Proactive Processing in Bipolar Disorder

NCT ID: NCT04561622

Last Updated: 2022-05-18

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 60 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2020-10-01
• Study Completion Date: 2022-10-01

Brief Summary

The main objective of this project is to identify behavioral specificities of the proactive emotional brain among bipolar patients, compared to healthy subjects. These could contribute to some of the emotional processing biases that can be observed in these patients. To achieve this goal, two behavioral tasks will be administer (emotional stroop and emotional stimuli categorization task) to bipolar patients and control subjects, and their performances will be compared.

Detailed Description

This is a case-control non-interventional study comparing bipolar patients to matched healthy controls during one assessment visit at the University Hospital of Grenoble.

The experimentation phase takes place in three stages: first, the experimenter collects demographic data (age and level of study, lack of medical history and treatments that may interfere with the task). For bipolar subjects, it also collects the type of bipolarity, the type and date of the last episode, the age of the onset of the disease and the treatment.

Secondly, the subject performs a classic Stroop task lasting 3 to 5 minutes, including instructions.

Finally, the subject performs the two main tasks: the emotional Stroop task lasting about 20 minutes and then the task of emotional stimuli categorization lasting about 15 minutes.

Conditions

Bipolar Disorder; Bipolar I Disorder; Bipolar II Disorder

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Study Groups

Bipolar patients

Bipolar patients (type I,II, NOS) of the bipolar disorder expert center of CHU Grenoble Alpes.

Emotional Stroop Task

Intervention Type: BEHAVIORAL

Classic Stroop task The subject names one of the 3 colors of the crosses on a sheet.Then, the subject must read the words written on the sheet for 45 seconds.These are the words: RED, BLUE and GREEN, written in black color. The subject must name the color of the word.

Emotional Stroop task This is a computed task in which the patient is asked to answer both as accurately and as quickly as possible.

The target stimulus is an emotional face of joy or anger, surmounted by the word "joy" or "anger".The subject must respond using the arrow corresponding to the face he sees.

A training phase is offered to the subject.

3 / Categorization task For each trial the participant will visualize a short emotional film or not. Then, the participant will have to choose, the emotion corresponding to what he just saw. A training period is offered too.

Healthy controls

Volunteers without any psychiatric disease matching inclusion criteria

Emotional Stroop Task

Intervention Type: BEHAVIORAL

Classic Stroop task The subject names one of the 3 colors of the crosses on a sheet.Then, the subject must read the words written on the sheet for 45 seconds.These are the words: RED, BLUE and GREEN, written in black color. The subject must name the color of the word.

Emotional Stroop task This is a computed task in which the patient is asked to answer both as accurately and as quickly as possible.

The target stimulus is an emotional face of joy or anger, surmounted by the word "joy" or "anger".The subject must respond using the arrow corresponding to the face he sees.

A training phase is offered to the subject.

3 / Categorization task For each trial the participant will visualize a short emotional film or not. Then, the participant will have to choose, the emotion corresponding to what he just saw. A training period is offered too.

Interventions

Emotional Stroop Task

Classic Stroop task The subject names one of the 3 colors of the crosses on a sheet.Then, the subject must read the words written on the sheet for 45 seconds.These are the words: RED, BLUE and GREEN, written in black color. The subject must name the color of the word.

Emotional Stroop task This is a computed task in which the patient is asked to answer both as accurately and as quickly as possible.

The target stimulus is an emotional face of joy or anger, surmounted by the word "joy" or "anger".The subject must respond using the arrow corresponding to the face he sees.

A training phase is offered to the subject.

3 / Categorization task For each trial the participant will visualize a short emotional film or not. Then, the participant will have to choose, the emotion corresponding to what he just saw. A training period is offered too.

Intervention Type: BEHAVIORAL

Other Intervention Names

Classic Stroop Task; Categorization of Emotional Stimuli Task

Eligibility Criteria

Inclusion Criteria

• Right-handed
• Francophones
• Bipolar disorder diagnosis (for patients) according to DSM-5 / CIM-10 criteria
• Affiliation to the French social security insurance

Exclusion Criteria

• uncorrected perceptual disturbance
• psychiatric disorders other than bipolarity as the main psychiatric disorder or a condition which may affect the tasks proposed for the patients' group
• subject under legal protection
• subject deprived of freedoms by a judicial or administrative decision
• drug abuse less than 12 hours before the assessment

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University Hospital, Grenoble

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Mircea Polosan, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Grenoble

Locations

CHU Grenoble Alpes

La Tronche, Isère, France

Countries

France

References

Beffara B, Wicker B, Vermeulen N, Ouellet M, Bret A, Molina MJ, Mermillod M. Reduction of interference effect by low spatial frequency information priming in an emotional Stroop task. J Vis. 2015;15(6):16. doi: 10.1167/15.6.16.

Reference Type: BACKGROUND

PMID: 26024463 (View on PubMed)

Golden, C. (1978). Diagnosis and Rehabilitation in Clinical Neuropsychology. College of Psychology: Faculty Books and Book Chapters. https://nsuworks.nova.edu/cps_facbooks/48

Reference Type: BACKGROUND

Other Identifiers

2019-A03026-51

Identifier Type: OTHER

Identifier Source: secondary_id

38RC19.387

Identifier Type: -

Identifier Source: org_study_id