Affective Processing in Depression and Epilepsy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

14 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-06-30

Study Completion Date

2009-06-30

Brief Summary

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The goal of this study is to determine whether there are unique markers on neuroimaging that are associated with depression in epilepsy.

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Detailed Description

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Symptoms of depression is commonly seen in patients with epilepsy. There are similarities and differences between depressive symptoms in epilepsy when compared with primary depression. Through the use of fMRI (Functional MRI), we hope to determine whether there are unique markers on neuroimaging that are associated with depression in epilepsy.

Conditions

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Epilepsy Depression Healthy

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Interventions

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fMRI

Subjects will undergo MRI scanning to gather data about cognetive functions.

Intervention Type OTHER

Hamilton Depression Rating Scale

Investigator will evalute the subject during a one on one interview for depression using the Hamilton Depression Rating Scale.

Intervention Type OTHER

Beck's Depressive Inventory

Subjects will complete self assessment to evaluate their level of depression.

Intervention Type OTHER

Interictal Dysphoric Disorder Inventory (IDDI)

Subject will complete self assessment to determine if there have been any changes in mood, emotions and or feelings from time to time.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Healthy adults of 18 years of age or older.

* Subject is at least 18 years of age
* Subject has confirmed temporal lobe epilepsy (TLE)

* Subject is at least 18 years of age
* Subject scores between 12 and 18 on Hamilton Depression Rating Scale

* Subject has confirmed temporal lobe epilepsy (TLE)
* Subject scores between 12 and 18 on Hamilton Depression Rating Scale

Exclusion Criteria

* Subject has no history of affective disorders
* Subject scores higher than 5 on Hamilton Depression Rating Scale
* Subject with prior primary diagnosis of any psychotic disorder, bipolar disorder, anxiety disorder, or any other serious medical or neurological disorder
* Subject is pregnant
* Subject is unable to undergo a MRI

Epilepsy Only Group

* Subject has a history of depression
* Subject scores higher then 5 on Hamilton Depression Rating Scale
* Subject with prior primary diagnosis of any psychotic disorder, bipolar disorder, anxiety disorder, or any other serious medical or neurological disorder
* Subject is pregnant
* Subject is unable to undergo a MRI

Depression Only Group

* Subject scores higher than 18 on Hamilton Depression Rating Scale
* Subject is currently being medicated for depression
* Subject has history of major depression or dysthymia
* Subject with prior primary diagnosis of any psychotic disorder, bipolar disorder, anxiety disorder, or any other serious medical or neurological disorder
* Subject is pregnant
* Subject is unable to undergo a MRI

Depression and Epilepsy Group

* Subject has history of major depression or dysthymia
* Subject is currently on medication for depression
* Subject with prior primary diagnosis of any psychotic disorder, bipolar disorder, anxiety disorder, or any other serious medical or neurological disorder
* Subject is pregnant
* Subject is unable to undergo a MRI

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes