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Female Experiences and Brain Activity

NCT ID: NCT01395160

Last Updated: 2013-09-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-07-31

Study Completion Date

2012-11-30

Brief Summary

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The Female Experiences and Brain Activity study will investigate how different groups of people process information in different ways. Using electro-physiological methods it will investigate differences in brain activity between women with ADHD, women with bipolar disorder and those without a psychiatric illness. It will also investigate the relationship between patterns of brain activity, mood and functioning.

Detailed Description

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Attention deficit hyperactivity disorder (ADHD) and bipolar disorder (BD) affect approximately 2.5% and 1%, respectively, of the adult population in the UK. They represent a major clinical and economic burden on society. Genetic and environmental risk factors (such as life events for BD); have been identified for each disorder. Despite the highly different symptom presentations for ADHD and BD, it has recently become clear that they share a cognitive characteristic, observed in high response time variability (RTV). This has led to the question of whether the increased RTV, which reflects short-term fluctuations in performance, is a non-specific marker for psychopathology or whether the causes for the higher RTV could differ across disorders. RTV has been identified as a possible early marker of psychopathology; therefore a better understanding of the underlying mechanisms could lead to improved diagnosis and prevention of negative consequences. Further, it will give insight into the comorbidity observed between ADHD and BD. This study will use cognitive-electrophysiological methods to investigate the causes for RTV and its association with other cognitive and neurophysiological impairments observed in each disorder (aim 1). The second question will address whether, within each disorder, current cognitive functioning relates to the patients' current social functioning (aim 2). Adverse life events and other psychosocial risk factors can contribute to high variability in the level of social functioning observed, within and between individuals, in each disorder; yet our understanding of the association between current social functioning and cognitive functioning is limited. Finally the study will explore if any cognitive differences detected by electrophysiological investigation are associated with any candidate gene markers for either disorder (aim 3).

Conditions

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Attention Deficit Hyperactivity Disorder ADHD Bipolar Disorder

Keywords

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Attention deficit hyperactivity disorder ADHD Bipolar Disorder Electrophysiological EEG ERP Attention Motivation Mood instability

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Adult ADHD

No interventions assigned to this group

Bipolar Disorder

No interventions assigned to this group

Healthy control

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* current clinical diagnosis of adult ADHD
* or current clinical diagnosis of Bipolar Disorder
* or no history of psychiatric illness
* white European descent

Exclusion Criteria

* presence of a neurodevelopmental disorder
* epilepsy
* brain injury
* dyslexia
* limited proficiency in English language
* IQ\<70
* any current psychiatric medication use (with the exception of mood stabilisers or stimulant medication in the clinical groups)
Minimum Eligible Age

25 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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South London and Maudsley NHS Foundation Trust

OTHER

Sponsor Role collaborator

King's College London

OTHER

Sponsor Role lead

Responsible Party

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Glenn Mould

Project Coordinator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Philip Asherson, MRCPsych, PhD

Role: PRINCIPAL_INVESTIGATOR

King's College London

Locations

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South London and Maudsley NHS Trust

London, London, United Kingdom

Site Status

Institute of Psychiatry, King's College London

London, London, United Kingdom

Site Status

Countries

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United Kingdom

Other Identifiers

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11/LO/0438

Identifier Type: -

Identifier Source: org_study_id