Canderel:Effects on Blood Glucose Concentration and Appetite Scores

NCT ID: NCT03232008

Last Updated: 2020-09-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

110 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-09-01

Study Completion Date

2021-03-28

Brief Summary

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This study investigates the effects of Canderel, an aspartame and acesulfame-k blend artificial sweetener powder, on post-postprandial blood glucose levels and appetite scores.

Detailed Description

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The study is separated into two parts: A) investigating the effects of artificial sweeteners in combination with complex carbohydrates; and B) investigating the effects of artificial sweeteners in combination with simple sugars.

A) Participants will be randomly given either the placebo drink (3g of maltodextrin dissolved in 250ml of water) or the Canderel drink (3g of Canderel dissolved in 250ml of water) alongside an isocaloric high carbohydrate breakfast. Blood glucose measurements will be obtained through finger pricking and appetite will be measured using self-reported visual analog scores rating hunger, desire to eat, fullness and alertness for up to 3 hours after breakfast.

B)Participants will be randomly given either the placebo drink (3g of Lyle's Golden syrup and 3g of maltodextrin dissolved in 250ml of water) or the Canderel+sugars drink (3g of Canderel and 3g of Lyle's Golden syrup dissolved in 250ml of water) . Blood glucose measurements will be obtained through finger pricking and appetite will be measured using self-reported visual analog scores rating hunger, desire to eat, fullness and alertness for up to 3 hours after drink

Conditions

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Appetitive Behavior Glucose Metabolism Disorders

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Experiment A- experimental

3g Canderel in 250ml water

Group Type EXPERIMENTAL

Canderel drink

Intervention Type DIETARY_SUPPLEMENT

1.4% aspartame and 0.95% acesulfame-k and 95% maltodextrin; 3g dissolved in 250ml of water

Experiment A- control

3g of maltodextrin in 250 ml of water

Group Type NO_INTERVENTION

No interventions assigned to this group

Experiment B- experimental

3g Canderel + 35g Lyle's Golden Syrup in 250 ml water

Group Type EXPERIMENTAL

Canderel+Lyle's Golden Syrup drink

Intervention Type DIETARY_SUPPLEMENT

Canderel: 1.4% aspartame and 0.95% acesulfame-k and 95% maltodextrin; 3g dissolved in 250ml of water Lyle's Golden Syrup: 35 g (27g of glucose and fructose)

Experiment B- control

3g Lyle's Golden Syrup + 35g of maltodextrin in 250 ml of water

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Canderel drink

1.4% aspartame and 0.95% acesulfame-k and 95% maltodextrin; 3g dissolved in 250ml of water

Intervention Type DIETARY_SUPPLEMENT

Canderel+Lyle's Golden Syrup drink

Canderel: 1.4% aspartame and 0.95% acesulfame-k and 95% maltodextrin; 3g dissolved in 250ml of water Lyle's Golden Syrup: 35 g (27g of glucose and fructose)

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Healthy male and female adults (18-64)

Exclusion Criteria

\-
Minimum Eligible Age

18 Years

Maximum Eligible Age

64 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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King's College London

OTHER

Sponsor Role lead

Responsible Party

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Dr Christopher Corpe

Nutrition Sciences Lecturer, Principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Dr. Christopher Corpe

Role: PRINCIPAL_INVESTIGATOR

King's College London

Locations

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King's College London

London, , United Kingdom

Site Status

Countries

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United Kingdom

Other Identifiers

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KCLMScNutr2017

Identifier Type: -

Identifier Source: org_study_id

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