Neurally Adjusted Ventilatory Assist (NAVA) vs Pressure Support Ventilation After Cardiac Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-08-30

Study Completion Date

2025-11-30

Brief Summary

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The study compares two different ventilation modes, Pressure support ventilation vs. Neuronally Adjusted Ventilatory Assist, in postcardiac surgery patients. Of special interest is shunt and alveolar deadspace and ventral vs. dorsal ventilation.

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Detailed Description

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The aim of the study is to compare two different ventilation modes in complicated postcardiac surgery patients, who need ventilatory support during weaning phase, in the Cardiothoracic Intensive Care Unit. The two different ventilation modes are Neuronally Adjusted Ventilatory Assist (NAVA) and Pressure Support ventilation. NAVA ventilation mode have been introduced a couple of years ago as an alternative to pressure support. The advantage of NAVA mode compared to pressure support is a better synchrony between patient and ventilator in the inspired and expired phases. Maybe there are also physiological advantages of the NAVA mode, which we want to study in the present study.

All patients have three measurement periods. 1) Pressure support during 20 min, NAVA equilibration period of 30 min, followed by 2) NAVA ventilation for 20 min, pressure support equilibration period of 30 min and 3) pressure support for 20 min. Blood gases and cardiac output measurements is performed before and after each measurement period. Regional ventilation is measured by Electric Impedance Tomography (EIT).

Conditions

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Ventilator Lung

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Control-Intervention-Control

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

The investigator works as physician at the Department of Intensive Care. The participants are patients.

Study Groups

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NAVA vs Pressure Support

Control (pressure support) - NAVA - Control (Pressure Support) Intervention is NAVA

Group Type OTHER

NAVA

Intervention Type DEVICE

Neurally Adjusted Ventilatory Assist is a fairly new ventilation mode

Interventions

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NAVA

Neurally Adjusted Ventilatory Assist is a fairly new ventilation mode

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Complicated Post Cardiac surgery patients in the ventilator weaning phase.
* Patients requiring assisted ventilation
* Respiratory and circulatory stable patients
* Sedated patients, RASS -2 to -3