Effect Alveolar Recruitment Manoeuver on Stroke Volume a Randomized Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

70 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-03-12

Study Completion Date

2022-04-01

Brief Summary

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Objective: to compare the effect of alveolar recruitment manouver through stepwise increase and decrease in airway pressure or sustained 30 secondes 30 cmH2O continuous positive airway pressure on cardiac stroke volume estimated by oesophageal doppler in preload independent anesthetized patients scheduled for surgery.

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Detailed Description

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Following anesthesia and preload optimisation guided by cardiac stroke volume, patients will be randomised to one alveolr recruitment manoeuver :

* stepwise increase and decrease in positive airway pressure
* sustained 30 secondes 30 cmH2O continuous positive airway pressure The primary objective is the change in cardiac stroke volume.

Conditions

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Alveolar Recruitment Manoeuver Anesthesia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

randomised parallel groups. randomisation between 2 groups equilibated by randomised blocks of 4, 6 or 8

Primary Study Purpose

OTHER

Blinding Strategy

DOUBLE

Participants Caregivers

The patient will not know the allocation group because he will be anesthetised before randomisation. The care provider (anesthetist) will not know the allocation group because the intervention will be applied by an independent investigator not involved in care of the patient.

Study Groups

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CPAP30

a 30 secondes 30 cmH2O continuous positive airway pressure applied after the orotracheal intubation will be checked and secured following induction of general anesthesia

Group Type ACTIVE_COMPARATOR

alveolar recruitment manoeuver

Intervention Type PROCEDURE

alveolar recruitment manoeuver are recommended during general anesthesia to prevent pulmonary atelectasis

STEP30

a stepwise increase (+5 cmH2O) in postivie airway pressure from +5 cmH2O to +30 cmH2O and decrease (-5 cmH2O) from +30 cmH2O to +5 cmH2O applied after the orotracheal intubation will be checked and secured following induction of general anesthesia

Group Type ACTIVE_COMPARATOR

alveolar recruitment manoeuver

Intervention Type PROCEDURE

alveolar recruitment manoeuver are recommended during general anesthesia to prevent pulmonary atelectasis

Interventions

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alveolar recruitment manoeuver

alveolar recruitment manoeuver are recommended during general anesthesia to prevent pulmonary atelectasis

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* adult patients scheduled for major surgery requiring hemodynamic monitoring
* written signed informed consent

Exclusion Criteria

* pregnancy
* non sinusal heart rate
* known cardiac right ventricular failure or arterial pulmonary hypertension
* pneumothorax
* known pulmonary emphysema

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No