The Effects of Dexmedetomidine on cTnI and GP-BB in Patients Undergoing OPCABG

NCT ID: NCT03163693

Last Updated: 2017-05-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-02-29

Study Completion Date

2017-05-31

Brief Summary

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The purpose of this study is to observe the impact of dexmedetomidine on Cardiac Troponin I and Glycogen Phosphorylase Isoenzyme BB in patients undergoing off-pump coronary artery bypass Grafting.

Detailed Description

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Dexmedetomidine is a highly selective α2-adrenoceptor agonist used as a sedative or adjuvant anesthetic drug in clinical settings.From clinical observation, dexmedetomidine has been revealed to reduce the incidence of cardiovascular adverse events in patients with heart diseases during non-cardiac surgeries.Therefore, the aim of this sudy is to observe the impact of dexmedetomidine on Cardiac Troponin I and Glycogen Phosphorylase Isoenzyme BB in patients during cardiac surgeries.

Conditions

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Coronary Artery Bypass, Off-Pump

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Group dexmedetomidine

20 eligible patients are received 0.5ug/kg dexmedetomidine intravenously 15 minutes before surgery

Group Type EXPERIMENTAL

dexmedetomidine

Intervention Type DRUG

receive dexmedetomidine 0.5 μg/kg

Group control

20 eligible patients are received equal volumes normal saline intravenously 15 minutes before surgery

Group Type PLACEBO_COMPARATOR

normal saline

Intervention Type OTHER

receive equal volume of normal saline

Interventions

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dexmedetomidine

receive dexmedetomidine 0.5 μg/kg

Intervention Type DRUG

normal saline

receive equal volume of normal saline

Intervention Type OTHER

Other Intervention Names

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Dex

Eligibility Criteria

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Inclusion Criteria

* Patients undergoing off - pump coronary artery bypass grafting
* ASA physical status III-IV
* Aged 40-70 years
* NYHA physical status II-III

Exclusion Criteria

* Bradycardia
* Atrioventricular block
* Echocardiography suggested:LVEF \<40%, LVED\>65mm
* Allergic to the drugs
Minimum Eligible Age

40 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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General Hospital of Ningxia Medical University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Zhu Di

Role: PRINCIPAL_INVESTIGATOR

General Hospital of Ningxia Medical University

Locations

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General Hospital of Ningxia Medical University

Yinchuan, Ningxia, China

Site Status

Countries

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China

Other Identifiers

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2015-NW-028

Identifier Type: -

Identifier Source: org_study_id

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