The Effect of Intranasally Administered Nitroglycerin on Hemodynamic Response to Laryngoscopy and Intubation Among Patients Undergoing Coronary Artery Bypass Grafting (CABG) Surgery

NCT ID: NCT06637956

Last Updated: 2024-10-15

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 58 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-01-01
• Study Completion Date: 2024-06-30

Brief Summary

Numerous preventive medications have been used to lessen the cardiovascular response to laryngoscopy and intubation. Though some advantages have been noted, most of these treatments have not been found to be completely satisfying. However, nitroglycerin is the most widely utilized medicine due to its fast effect, short half-life, and absence of sedative qualities.

Detailed Description

The circulatory system under compromise is less resilient to the effects of general anaesthesia. Inducing anaesthesia is a crucial step for cardiac patients because their impaired circulatory systems are less tolerant to depression. During coronary artery bypass grafting surgery, the primary objective of general anesthesia is to reduce sympathetic response to uncomfortable stimuli, including laryngoscopy, intubation, skin incision, sternal splitting, and spreading. A rise in blood pressure is one of the hemodynamic reactions that is typically associated with tracheal intubation and laryngoscopy. The impact of intra nasally delivered nitroglycerin on blood pressure response to laryngoscopy and intubation in patients having non-cardiac surgery is currently contentious; however, this study focus on coronary artery bypass grafting surgery patients.

Conditions

Coronary Artery Bypass Grafting

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

NTG

Received a mg nitroglycerin intranasally two minutes prior to laryngoscopy and intubation

Group Type: EXPERIMENTAL

Nitroglycerin (NTG)

Intervention Type: DRUG

Received 1 mg of nitroglycerin intranasally two minutes prior to laryngoscopy and intubation

Control

Control group did not receive nitroglycerine prior to laryngoscopy and intubation

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

Nitroglycerin (NTG)

Received 1 mg of nitroglycerin intranasally two minutes prior to laryngoscopy and intubation

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Both genders
• Patients undergoing coronary artery bypass grafting surgery.
• Patients aged 35-60 years.
• Ejection Fraction between 50-60%.
• American Society of Anesthesiologists Classification 3-4.

Exclusion Criteria

• Known hypersensitivity to nitroglycerin.
• Anticipated difficult airway.
• Emergency surgery.

• Minimum Eligible Age: 35 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Muhammad Aamir Latif

OTHER

Sponsor Role: lead

Responsible Party

Muhammad Aamir Latif

Research Consultant

Responsibility Role: SPONSOR_INVESTIGATOR

Principal Investigators

Shehryar Ahmed, MS

Role: PRINCIPAL_INVESTIGATOR

Department of anesthesia Rashid Latif Medical college, Lahore, Pakistan

Syed Shakeel Ahmed, FCPS

Role: PRINCIPAL_INVESTIGATOR

Department of Anesthesia, Shahida Islam Teaching Hospital, Lodhran, Pakistan

Locations

Department of Anesthesia, Rashid Latif Medical College

Lahore, Punjab Province, Pakistan

Countries

Pakistan

Other Identifiers

PIC_Lahore

Identifier Type: -

Identifier Source: org_study_id