Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
40 participants
INTERVENTIONAL
2017-01-09
2018-12-31
Brief Summary
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An additional goal is to identify non-responders at an early stage, where prevention strategies (pharmacologically or by specific training) will be successful.
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
PREVENTION
NONE
Interventions
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exercise training
Eligibility Criteria
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Inclusion Criteria
* overweight (BMI\>27 kg/m2)
* impaired fasting glucose and/ or glucose tolerance
* former gestational diabetes
* family history for type 2 diabetes (first-degree relative)
* sedentary participant (\< 2 exercise bouts/week)
Exclusion Criteria
* thermosensory or heightened sensitivity to heating
* heightened sensitivity to loud noise or diseases of the ear
* claustrophobia
* Diabetes mellitus
* current pregnancy or breastfeeding
* cardiovascular diseases
* surgery, \< 3 months ago
* participation in other clinical trials
* acute illness/infection, \< 4 weeks ago
* severe mental illness
* hemoglobin, women \< 11g/dl, men \< 13g/dl
* potentially incompliant subjects and/or inability to absolve the exercise training
* glucose influencing drugs
* continuous analgetic drugs
* use of anticoagulants
18 Years
65 Years
ALL
Yes
Sponsors
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University Hospital Tuebingen
OTHER
Responsible Party
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Dr. Anja Boehm
Dr. med. (MD)
Principal Investigators
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Hans-Ulrich Häring, Prof.
Role: STUDY_DIRECTOR
University Hospital Tuebingen
Locations
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Institute for Diabetes research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen
Tübingen, , Germany
Countries
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References
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Kullmann S, Goj T, Veit R, Fritsche L, Wagner L, Schneeweiss P, Hoene M, Hoffmann C, Machann J, Niess A, Preissl H, Birkenfeld AL, Peter A, Haring HU, Fritsche A, Moller A, Weigert C, Heni M. Exercise restores brain insulin sensitivity in sedentary adults who are overweight and obese. JCI Insight. 2022 Sep 22;7(18):e161498. doi: 10.1172/jci.insight.161498.
Hoffmann C, Schneeweiss P, Randrianarisoa E, Schnauder G, Kappler L, Machann J, Schick F, Fritsche A, Heni M, Birkenfeld A, Niess AM, Haring HU, Weigert C, Moller A. Response of Mitochondrial Respiration in Adipose Tissue and Muscle to 8 Weeks of Endurance Exercise in Obese Subjects. J Clin Endocrinol Metab. 2020 Nov 1;105(11):dgaa571. doi: 10.1210/clinem/dgaa571.
Other Identifiers
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446/2016BO2
Identifier Type: -
Identifier Source: org_study_id
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