Effect of Hypotensive Anesthesia on the Perfusion Index

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

EARLY_PHASE1

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-06-10

Study Completion Date

2017-04-21

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Controlled hypotension has been used as a mean of reducing intraoperative blood loss and better visualization of the surgical field in nasal surgeries. Perfusion index has been considered a useful tool for monitoring changes in peripheral perfusion using Masimo set and serum lactate for central perfusion. Many medications were used to induce hypotension. In this study we will compare the effects of tridil and labetalol on the perfusion.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Perfusion Index as a Predictor of Postinduction Hypotension of General Anesthesia in Geriatric Patients

NCT04682717

Hypotension on Induction

COMPLETED

Effects Magnesium Sulfate and Labetalol Infusion on Peripheral Perfusion and Pain in Nasal Surgeries

NCT04688203

Peripheral Perfusion Postoperative Pain

COMPLETED PHASE1/PHASE2

Peripheral Perfusion Index as a Predictor of Post-spinal Hypotension in Patients Undergoing Lower Limb Surgeries

NCT07279805

Post Spinal Anaesthesia Hypotension

COMPLETED

HPI in Older Patients Undergoing Major Gastrointestinal Surgery

NCT05297318

the Severity and Duration of Intraoperative Hypotension

COMPLETED NA

Predictor of Postoperative Complications After Lengthy Noncardiac Surgery

NCT04680663

Peripheral Perfusion Index

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The purpose of this study to detect the degree of hypotension that helps the surgeon and dosen't impair patient's perfusion and to compare the hypotensive effects of both tridil and labetalol infusions on the perfusion.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Controlled Hypotension for Nasal Surgeries

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

SEQUENTIAL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

SINGLE

Investigators

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

nitroglycerin group

this group will receive nitroglycerin infusion for controlled hypotension.0.5-5ug/kg/min to keep MAP 55-65mmhg then Massimo device will be attached to the patients when MAP reached the desired level

Group Type ACTIVE_COMPARATOR

Massimo device

Intervention Type COMBINATION_PRODUCT

Massimo is a newly introduced device which can measure the peripheral organ perfusion and expressed it as perfusion index(PI).

Nitroglycerin drug

Intervention Type DRUG

Nitroglycerin is a drug used as an hypotensive agent through its vasodilation effect on veins

labetalol group

this group will receive labetalol infusion fo controlled hypotension 0.4-3mg/kg/hr to keep MAP 55-65mmhg.then Massimo device will be attached to the patients when MAP reached the desired level

Group Type ACTIVE_COMPARATOR

Massimo device

Intervention Type COMBINATION_PRODUCT

Massimo is a newly introduced device which can measure the peripheral organ perfusion and expressed it as perfusion index(PI).

Labetalol

Intervention Type DRUG

Labetalol is an antagonist of adrenergic receptors (a1, b1, b2) which is used as an hypotensive inducer. This drug targets the beta receptors 5 to 10 times more specific than alpha receptors so that minor tachycardia happens

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Massimo device

Massimo is a newly introduced device which can measure the peripheral organ perfusion and expressed it as perfusion index(PI).

Intervention Type COMBINATION_PRODUCT

Nitroglycerin drug

Nitroglycerin is a drug used as an hypotensive agent through its vasodilation effect on veins

Intervention Type DRUG

Labetalol

Labetalol is an antagonist of adrenergic receptors (a1, b1, b2) which is used as an hypotensive inducer. This drug targets the beta receptors 5 to 10 times more specific than alpha receptors so that minor tachycardia happens

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

tridil trendate

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* ASA I-II males and females aged 18-45 years who were scheduled for Functional Endoscopic sinus surgery (FESS)

Exclusion Criteria

* uncontrolled hypertension, cerebrovascular disorders, bleeding and coagulation disorders, coronary artery diseases, renal or hepatic diseases or known hypersensitivity to the drugs used and pregnant.

Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes