Determination of the ED50 and ED95 of Prophylactic Norepinephrine Infusion for Preventing Post-induction Hypotension in Elderly Patients Undergoing Major Abdominal Surgery
NCT ID: NCT05637164
Last Updated: 2022-12-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
40 participants
INTERVENTIONAL
2022-12-01
2023-05-30
Brief Summary
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What is the effective concentration of prophylactic norepinephrine infusion for preventing post-induction hypotension in elderly patients.
Participants will receive different concentrations of norepinephrine infusion at the beginning of anesthesia induction until 15 minutes after intubation.
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
PREVENTION
NONE
Study Groups
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Norepinephrine
norepinephrine bitartrate
The treatment group will receive a continuous infusion of norepinephrine at the beginning of anesthesia induction until 15 minutes after intubation. The dosage of norepinephrine was decided by the up-and-down sequential allocation method with an initial dose of 0.05 µg/kg/min and a 0.005 µg/kg/min gradient.
Interventions
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norepinephrine bitartrate
The treatment group will receive a continuous infusion of norepinephrine at the beginning of anesthesia induction until 15 minutes after intubation. The dosage of norepinephrine was decided by the up-and-down sequential allocation method with an initial dose of 0.05 µg/kg/min and a 0.005 µg/kg/min gradient.
Eligibility Criteria
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Inclusion Criteria
* Undergoing major abdominal surgery
* American Society of Anesthesiologists (ASA) physical status of I/II/III
Exclusion Criteria
* Severe untreated or uncontrolled hypertension despite medications
* Bradycardia (heart rate \< 50 beat per minute)
* Cardiac morbidities, heart block greater than the first degree
* Severe hepatic and renal dysfunction
* hyperthyroidism
* vascular diseases
* BMI\>30
* Monoamine oxidase inhibitors were used 2 weeks before surgery
65 Years
80 Years
ALL
No
Sponsors
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Second Affiliated Hospital, School of Medicine, Zhejiang University
OTHER
Responsible Party
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Locations
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The Second Affiliated Hospital of Zhejiang University Medical College
Hangzhou, Zhejiang, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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2022-0950
Identifier Type: -
Identifier Source: org_study_id
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