Prophylactic Noradrenaline Infusion and Its Impact on Post-induction Hypotension

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-06-22

Study Completion Date

2025-09-17

Brief Summary

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researchers aim to evaluate the influence of prophylactic noradrenaline infusion on post-induction hypotension

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Detailed Description

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If post-induction hypotension is not addressed promptly, it can lead to severe complications such as reduced blood flow, acute kidney damage, and myocardial ischemia. As a result, early detection and proactive intervention are crucial. Researchers of the current study decided to investigate impact of noradrenaline administered as a prophylaxis on post induction hypotension

Conditions

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Post Induction Hypotension Sepsis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Noradrenaline

Noradrenaline will be infused at a fixed rate of 0.2 mic/kg/min at 5 minutes before induction

Group Type ACTIVE_COMPARATOR

Noradrenaline 0.2 mcg/kg/min at 5 minutes before induction

Intervention Type DRUG

noradrenaline will be given at a rate of 0.2 mcg/kg/min that will start 5 minutes before induction

Control

Patients will receive normal saline

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Noradrenaline 0.2 mcg/kg/min at 5 minutes before induction

noradrenaline will be given at a rate of 0.2 mcg/kg/min that will start 5 minutes before induction

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Adult patients with sepsis undergoing source control surgery.

Exclusion Criteria

* Patient refusal
* Patient with cardiac pathology ( ischemic heart disease or heart failure)
* Preoperative hemodynamic instability (defined as MAP \< 65 mmHg)
* Rapid sequence induction

Minimum Eligible Age

20 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No