Pharmacological Recruitment of Endogenous Neural Precursors to Promote Pediatric White Matter Repair: Establishing Correlations Between Visual Outcomes, Saccadic Function and MEG Oscillations in Children With Demyelinating Disorders in Comparison to Healthy Control Children

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

78 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-12-31

Study Completion Date

2018-11-16

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The neural circuits in our brains require a layer of insulation in order to transmit signals in a rapid and efficient fashion. This insulation is called White Matter and is comprised of a specific type of brain cell called an oligodendrocytes. Damage to brain white matter occurs following injury and in disorders like Multiple Sclerosis and results in sensory, motor, and cognitive problems. Currently there are no effective medical therapies to promote brain repair and reduce disability following damage to white matter. In this project, we hope to change the situation by encouraging the brain itself to generate new oligodendrocytes and thus new white matter. Our first step is to find measures sensitive to white matter growth.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Eyetracking and Neurovision Rehabilitation of Oculomotor Dysfunction in Mild Traumatic Brain Injury

NCT03319966

Mild Traumatic Brain Injury Brain Concussion Convergence Insufficiency +3 more

COMPLETED

Visual Rehabilitation in Children With Homonymous Hemianopia: a Pilot Study on Virtual-reality Stimulation

NCT05065268

Hemianopia Brain Tumor Children, Only

COMPLETED NA

Children's Health Research Institute(CHRI), Stanford Lucile Packard Children Hospital (LPCH) Protocol on Myotonic Dystrophy

NCT02269865

Myotonic Dystrophy Type 1

UNKNOWN

Improving Visual Field Deficits With Noninvasive Brain Stimulation

NCT05085210

Visual Field Defect, Peripheral Stroke Visual Impairment +6 more

RECRUITING NA

MRI Screening for Auditory Pathway Malformations in Visually Impaired Children

NCT02896738

Visual Impairment

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Demyelinating Disease

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

40 Demyelinating Disease patients

No interventions assigned to this group

40 Non-patient participants

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Experienced a demyelinating event (Only applicable to patient subjects)
* Between the ages of 5 years to 18 years and 11 months of age
* Has either English as his or her native language or has had at least two years of schooling in English

Exclusion Criteria

* Children with non-demyelinating etiologies of white matter dysfunction (i.e., metabolic disorders, vasculitis, and non-specific MRI abnormalities
* Is younger than 5 years of age
* Is 18 years and 11 of age or older
* Has a prior history of traumatic brain injury, neurological disorder, cerebral palsy, developmental delay, or learning disability
* Requires sedation for brain scanning
* Is claustrophobic, as brain scanning requires children to enter a tunnel in the MRI machine

Minimum Eligible Age

5 Years

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes