Restoring Neural Oscillatory Communication in Developmental Dyslexia

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

78 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-12-14

Study Completion Date

2024-12-23

Brief Summary

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Developmental dyslexia (DD) is a multifactorial disorder that hampers the education of about 10% of individuals across cultures and is associated to both phonological and visual deficits. The latter have been linked to a deficit in the magnocellular-dorsal (M-D) visual stream, that has a critical role in guiding the activity of ventral visual stream areas where letters identity is extracted. Here, we will test the efficacy of transcranial alternate current stimulation (tACS) of the M-D stream combined with reading trainings in adult participants with DD, assessing the neurophysiological underpinnings of these new trainings with EEG and fMRI/DTI.

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Detailed Description

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Conditions

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Developmental Dyslexia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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Group DD1

tACS + visuo-attentional training

Group Type EXPERIMENTAL

Parietal tACS combined with visuo-attentional training

Intervention Type DEVICE

Parietal tACS combined with visuo-attentional training

Group DD2

Sham (placebo) tACS + visuo-attentional training

Group Type ACTIVE_COMPARATOR

Sham (placebo) tACS combined with visuo-attentional training

Intervention Type DEVICE

Sham (placebo) tACS combined with visuo-attentional training

Group DD3

Sham (placebo) tACS + phonics training

Group Type ACTIVE_COMPARATOR

Sham (placebo) tACS combined with phonics training

Intervention Type DEVICE

Sham (placebo) tACS combined with phonics training

Interventions

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Parietal tACS combined with visuo-attentional training

Intervention Type DEVICE

Sham (placebo) tACS combined with visuo-attentional training

Intervention Type DEVICE

Sham (placebo) tACS combined with phonics training

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Adult patient (age between 18 and 35)
* Official Diagnosis of Developmental Dyslexia (DD)
* Normal or corrected-to-normal vision and hearing
* Normal motor skills

Exclusion Criteria

* Participants that cannot sign the consent form
* Participants unable to read or understand and correctly complete the procedures foreseen by the study
* Participants with a diagnosis or personal history of epilepsy or patients with a positive family history of epilepsy
* Pregnant or breastfeeding patients
* Participants with major psychiatric or neurological disorders and/or currently in psychopharmacological treatments.
* Participants with metal implants in the brain, pacemakers, brain stimulators, cochlear implants.
* Participants with claustrophobia (only for fMRI)

Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes