Determining Whether Multiple Anesthesia Exposures Affect Cognitive Function for Retinoblastoma Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

75 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-05-07

Study Completion Date

2026-05-07

Brief Summary

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The purpose of this study is to see if there is a difference between the development of the brain (neurodevelopment) in children who have been treated for retinoblastoma with multiple anesthetic exposures, compared with brain development in children who have never had anesthesia.

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Detailed Description

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Conditions

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Pediatric Retinoblastoma Retinoblastoma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Wechsler Intelligence Scale for Children, Fifth Edition (WISC-V)

the WISC-V assessment produces a Full Scale IQ (FSIQ) used for primary power consideration in this study. The FSIQ is the most comprehensive global ability score on the WISC-V, and it has been conventionally reported and interpreted as an estimation of overall intellectual ability

Intervention Type OTHER

California Verbal Learning Test, Children's Version

Used to assess verbal learning and memory in children and adolescents

Intervention Type OTHER

Beery Developmental Test of Visual Motor Integration, 6th edition

Helps assess visual-motor skills in children and adults.

Intervention Type OTHER

Grooved Pegboard Test

Measures dexterity

Intervention Type OTHER

Behavior Assessment System for Children/Parent Report

The Behavior Assessment System for Children/Parent Report is a questionnaire that assesses the social-emotional and behavioral functioning (e.g., anxiety, depression, attention, hyperactivity, adaptability, leadership, social skills, etc.) in children between the ages of 2 and 22 years, and is available in English and Spanish.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age ≥ 6 and \< 17 years old

Exclusion Criteria

* Diagnosis of any secondary disease associated with developmental delay
* History of second cancer diagnosis
* Legal Blindness
* Past surgery of any type, with the exception of enucleation for retinoblastoma
* Past exposure to anesthesia for surgical intervention
* More than one anesthesia encounter for surgical intervention before diagnosis at MSK
* Past External Beam Radiation for treatment of retinoblastoma
* Past systemic chemotherapy
* Non-native speaker of English; however, children whose parents speak only Spanish will be included, because the tests for parents are available in Spanish

Minimum Eligible Age

6 Years

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No