Evaluation of Visual - Motor Development in Children With Retinopathy of Prematurity

NCT ID: NCT03865134

Last Updated: 2020-03-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

69 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-09-20

Study Completion Date

2019-04-25

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The aim of this study was to investigate the eye structure, visual impairment, visual motor development and motor coordination of children between 2-6 ages that had applied to diod laser photocoagulation and intravitreal anti - vascular endothelial growth factor treatment.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

There are three different groups in this study. Children between 2-6 ages that had applied to diod laser photocoagulation and intravitreal anti - vascular endothelial growth factor treatment will have evaluated with Snellen Test, Titmus Fly Test, Optical Kohlerans Tomography, Beery-Buktenica Developmental Test of Visual Motor Integration, Peabody Developmental Motor Scales-II, World Health Organization Quality of Life - BREF and State - Trait Anxiety Inventory.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Premature Retinopathy Visual Impairment Motor Delay

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Laser Group

Children with premature retinopathy treated with Laser therapy. All cases are evaluated with Snellen Test, Autorefractometer, Titmus Stereo Fly Test, Optical Kohlerans Tomography, Peabody Developmental Motor Scales - II. Investigation of Visual Motor Integration will evaluate with Beery- Buktenica Developmental Test of Visual Motor Integration and Peabody. Parents are evaluated World Health Organization Quality of Life - BREF and State - Trait Anxiety Inventory.

Snellen Test

Intervention Type DIAGNOSTIC_TEST

Visual acuity measurement

Autorefractometer

Intervention Type DIAGNOSTIC_TEST

Refraction measurement

Titmus Stereo Fly Test

Intervention Type DIAGNOSTIC_TEST

Stereopsis measurement

Optical Kohlerans Tomography

Intervention Type DIAGNOSTIC_TEST

Retinal development measurement

Investigation of Visual Motor Integration

Intervention Type BEHAVIORAL

Investigation of visual motor integration, motor coordination and visual perception by Beery- Buktenica Developmental Test of Visual Motor Integration.

Peabody Developmental Motor Scales - II

Intervention Type BEHAVIORAL

Evaluation of motor development

World Health Organization Quality of Life - BREF

Intervention Type BEHAVIORAL

Assesment of quality of life

State - Trait Anxiety Inventory

Intervention Type BEHAVIORAL

Assesment of anxiety

Anti-VEGF Group

Children with premature retinopathy treated with anti-VEGF therapy. All cases are evaluated with Snellen Test, Autorefractometer, Titmus Stereo Fly Test, Optical Kohlerans Tomography, Peabody Developmental Motor Scales - II. Investigation of Visual Motor Integration will evaluate with Beery- Buktenica Developmental Test of Visual Motor Integration and Peabody. Parents are evaluated World Health Organization Quality of Life - BREF and State - Trait Anxiety Inventory.

Snellen Test

Intervention Type DIAGNOSTIC_TEST

Visual acuity measurement

Autorefractometer

Intervention Type DIAGNOSTIC_TEST

Refraction measurement

Titmus Stereo Fly Test

Intervention Type DIAGNOSTIC_TEST

Stereopsis measurement

Optical Kohlerans Tomography

Intervention Type DIAGNOSTIC_TEST

Retinal development measurement

Investigation of Visual Motor Integration

Intervention Type BEHAVIORAL

Investigation of visual motor integration, motor coordination and visual perception by Beery- Buktenica Developmental Test of Visual Motor Integration.

Peabody Developmental Motor Scales - II

Intervention Type BEHAVIORAL

Evaluation of motor development

World Health Organization Quality of Life - BREF

Intervention Type BEHAVIORAL

Assesment of quality of life

State - Trait Anxiety Inventory

Intervention Type BEHAVIORAL

Assesment of anxiety

Regrese Group

Children with premature retinopathy haven't applied any invasive treatment method. All cases are evaluated with Snellen Test, Autorefractometer, Titmus Stereo Fly Test, Optical Kohlerans Tomography, Peabody Developmental Motor Scales - II. Investigation of Visual Motor Integration will evaluate with Beery- Buktenica Developmental Test of Visual Motor Integration and Peabody. Parents are evaluated World Health Organization Quality of Life - BREF and State - Trait Anxiety Inventory.

Snellen Test

Intervention Type DIAGNOSTIC_TEST

Visual acuity measurement

Autorefractometer

Intervention Type DIAGNOSTIC_TEST

Refraction measurement

Titmus Stereo Fly Test

Intervention Type DIAGNOSTIC_TEST

Stereopsis measurement

Optical Kohlerans Tomography

Intervention Type DIAGNOSTIC_TEST

Retinal development measurement

Investigation of Visual Motor Integration

Intervention Type BEHAVIORAL

Investigation of visual motor integration, motor coordination and visual perception by Beery- Buktenica Developmental Test of Visual Motor Integration.

Peabody Developmental Motor Scales - II

Intervention Type BEHAVIORAL

Evaluation of motor development

World Health Organization Quality of Life - BREF

Intervention Type BEHAVIORAL

Assesment of quality of life

State - Trait Anxiety Inventory

Intervention Type BEHAVIORAL

Assesment of anxiety

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Snellen Test

Visual acuity measurement

Intervention Type DIAGNOSTIC_TEST

Autorefractometer

Refraction measurement

Intervention Type DIAGNOSTIC_TEST

Titmus Stereo Fly Test

Stereopsis measurement

Intervention Type DIAGNOSTIC_TEST

Optical Kohlerans Tomography

Retinal development measurement

Intervention Type DIAGNOSTIC_TEST

Investigation of Visual Motor Integration

Investigation of visual motor integration, motor coordination and visual perception by Beery- Buktenica Developmental Test of Visual Motor Integration.

Intervention Type BEHAVIORAL

Peabody Developmental Motor Scales - II

Evaluation of motor development

Intervention Type BEHAVIORAL

World Health Organization Quality of Life - BREF

Assesment of quality of life

Intervention Type BEHAVIORAL

State - Trait Anxiety Inventory

Assesment of anxiety

Intervention Type BEHAVIORAL

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Age range between 2-6 years of age
* Gestational age range 26-34. be between weeks
* To be diagnosed with retinopathy of prematurity
* Neurological, hereditary and not having metabolic disease
* Compliance with visual examinations and physiotherapy evaluations
* To be children and parents who agree to participate in the study

Exclusion Criteria

* To be a child who does not comply with Optical Kohlerans Tomography (OCT)
* Not participating in one or more of the eye examination or physiotherapy assessments
* Being children and parents who do not agree to participate in the study
Minimum Eligible Age

2 Years

Maximum Eligible Age

6 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Istanbul Medipol University Hospital

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Zeliha Candan Algun

Role: STUDY_DIRECTOR

Istanbul Medipol University Hospital

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Istanbul Medipol University

Istanbul, Beykoz, Turkey (Türkiye)

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Turkey (Türkiye)

References

Explore related publications, articles, or registry entries linked to this study.

Rothman AL, Mangalesh S, Chen X, Toth CA. Optical coherence tomography of the preterm eye: from retinopathy of prematurity to brain development. Eye Brain. 2016 May 27;8:123-133. doi: 10.2147/EB.S97660. eCollection 2016.

Reference Type BACKGROUND
PMID: 28539807 (View on PubMed)

Kabatas EU, Kurtul BE, Altiaylik Ozer P, Kabatas N. Comparison of Intravitreal Bevacizumab, Intravitreal Ranibizumab and Laser Photocoagulation for Treatment of Type 1 Retinopathy of Prematurity in Turkish Preterm Children. Curr Eye Res. 2017 Jul;42(7):1054-1058. doi: 10.1080/02713683.2016.1264607. Epub 2017 Jan 27.

Reference Type BACKGROUND
PMID: 28128986 (View on PubMed)

Araz-Ersan B, Kir N, Tuncer S, Aydinoglu-Candan O, Yildiz-Inec D, Akdogan B, Ekici B, Demirel A, Ozmen M. Preliminary anatomical and neurodevelopmental outcomes of intravitreal bevacizumab as adjunctive treatment for retinopathy of prematurity. Curr Eye Res. 2015 May;40(6):585-91. doi: 10.3109/02713683.2014.941070. Epub 2014 Jul 15.

Reference Type RESULT
PMID: 25025864 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

10840098-604.01.01-E.34158

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.