Anesthesia and Motor Evoked Potential (MEP) Recruitment

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-03-31

Study Completion Date

2017-03-31

Brief Summary

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Test the hypothesis to recruit larger motor responses to transcranial stimulation.

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Detailed Description

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The study is designed to test the hypothesis that it is possible to recruit larger motor responses to transcranial stimulation by increasing the number of stimulating pulses under both baseline conditions and conditions of increased anesthetic suppression of the motor responses.

Conditions

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Idiopathic Scoliosis

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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desflurane MEP's

Transcranial motor evoked potentials are obtained under total intravenous anesthesia (TIVA) and again after desflurane at 3%, for at least 5 minutes.at two different time points. Each subject is his/her own control

Group Type EXPERIMENTAL

Desflurane

Intervention Type DRUG

Interventions

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Desflurane

Intervention Type DRUG

Other Intervention Names

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Suprane

Eligibility Criteria

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Inclusion Criteria

* Age 12 through 17 years
* Diagnosis of idiopathic scoliosis
* Scheduled for posterior spinal fusion with neurophysiological monitoring
* No known allergies to propofol or remifentanil
* No contraindication to total intravenous anesthesia
* No contraindications to the administration of volatile agents

Exclusion Criteria

* Failure to consent or assent to study
* Diagnosis other than idiopathic scoliosis
* Poorly controlled seizures or the presence of a cochlear implant
* Patient history or family history of malignant hypothermia or mitochondrial myopathies

Minimum Eligible Age

12 Years

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No