Novel Evaluation of Aspirated Follicular Fluid

NCT ID: NCT02999555

Last Updated: 2017-08-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-02-01

Study Completion Date

2018-12-31

Brief Summary

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A molecular study of follicular fluid aspirated from ovarian follicles during routine in vitro fertilization treatment, after the eggs were identified and separated.

Detailed Description

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Ovarian stimulation is a routine part of in vitro fertilization treatment: this process involves an inflammatory response in the developing follicles. We still do not completely understand the complex interactions leading to the maturation of the egg and the multiple interactions of the egg with its supporting cells. In this study we will assess follicular fluid, letf over after the eggs were identified and separated, for the presence of inflammatory mediators, dendritic cells , vasorin and soluble Flt1. The presence and quantification of these factors, as well as their correlation with the size of the aspirated follicle is the focus of this study.

Conditions

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Ovary Inflammation

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Aspirated follicular fluid

Follicular fluid aspirated by follicle size and tested for the novel markers after eggs were identified and separated for the purpose of fertilization

Group Type EXPERIMENTAL

Ovum pickup

Intervention Type PROCEDURE

Ovum pickup or Egg retrieval, that is performed not for the purpose of the study, but for the purpose of well known in vitro fertilization indications

Interventions

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Ovum pickup

Ovum pickup or Egg retrieval, that is performed not for the purpose of the study, but for the purpose of well known in vitro fertilization indications

Intervention Type PROCEDURE

Other Intervention Names

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Egg retrieval

Eligibility Criteria

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Inclusion Criteria

* All women going through a fertility/ fertility preservation indicated egg retrieval in the in vitro fertilization (IVF) unit in 'Meir medical center',
* Patients' informed consent

Exclusion Criteria

* Patients refusing to take part in the study
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Weizmann Institute of Science

OTHER

Sponsor Role collaborator

Meir Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Anat Hershko Klement

Dr Anat Hershko Klement

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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MEIR medical center REB committee REB committee

Role: STUDY_CHAIR

Tel Aviv University

Locations

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Meir Medical Center

Kfar Saba, , Israel

Site Status RECRUITING

Countries

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Israel

Central Contacts

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Anat Hershko Klement, MD

Role: CONTACT

972549170084

Facility Contacts

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Anat Hershko Klement, MD

Role: primary

972549170084

References

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Wulff C, Wiegand SJ, Saunders PT, Scobie GA, Fraser HM. Angiogenesis during follicular development in the primate and its inhibition by treatment with truncated Flt-1-Fc (vascular endothelial growth factor Trap(A40)). Endocrinology. 2001 Jul;142(7):3244-54. doi: 10.1210/endo.142.7.8258.

Reference Type BACKGROUND
PMID: 11416048 (View on PubMed)

Gruemmer R, Motejlek K, Berghaus D, Weich HA, Neulen J. Regulation of soluble vascular endothelial growth factor receptor (sFlt-1/sVEGFR-1) expression and release in endothelial cells by human follicular fluid and granulosa cells. Reprod Biol Endocrinol. 2005 Oct 25;3:57. doi: 10.1186/1477-7827-3-57.

Reference Type BACKGROUND
PMID: 16248895 (View on PubMed)

Other Identifiers

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MMC160192-16CTIL

Identifier Type: -

Identifier Source: org_study_id

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