Human Follicular Fluid Markers and Reproductive Outcomes in IVF
NCT ID: NCT05893238
Last Updated: 2023-11-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
200 participants
OBSERVATIONAL
2023-10-02
2025-06-30
Brief Summary
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Furthermore, the investigators want to investigate if there are differences between IVF treatments with or without hormonal stimulation of the ovaries.
Detailed Description
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The investigators want to
* compare the follicular fluid values between the two IVF treatment groups.
* assess the associations and predictive power of follicular fluid / blood and sperm parameters for success of the IVF treatment.
* compare the IVF success in the two treatment groups. The study aims to enrol approximately 200 couples. The data will be collected by the physicians and added to the REDcap study registry. Access to the total data set is only permitted for the principal investigator.
Conditions
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Keywords
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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In Vitro Fertilisation (IVF)-Patients without hormonal stimulation (Natural cycle IVF)
Natural cycle IVF
Natural cycle In Vitro Fertilisation (IVF)
In Vitro Fertilisation (IVF) without hormonal stimulation
Blood samples for analysis
Test hormone levels in serum
Follicular fluid for analysis
Test hormone levels in follicular fluid Test Oxidation-reduction potential
Sperm samples for analysis
Oxidation-reduction potential
In Vitro Fertilisation (IVF)-Patients with hormonal stimulation (conventional IVF)
conventional IVF
Blood samples for analysis
Test hormone levels in serum
Follicular fluid for analysis
Test hormone levels in follicular fluid Test Oxidation-reduction potential
Sperm samples for analysis
Oxidation-reduction potential
Conventional In Vitro Fertilisation (IVF)
In Vitro Fertilisation (IVF) with conventional hormonal stimulation
Interventions
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Natural cycle In Vitro Fertilisation (IVF)
In Vitro Fertilisation (IVF) without hormonal stimulation
Blood samples for analysis
Test hormone levels in serum
Follicular fluid for analysis
Test hormone levels in follicular fluid Test Oxidation-reduction potential
Sperm samples for analysis
Oxidation-reduction potential
Conventional In Vitro Fertilisation (IVF)
In Vitro Fertilisation (IVF) with conventional hormonal stimulation
Eligibility Criteria
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Inclusion Criteria
* Written consent
* Couples undergoing In Vitro Fertilisation (natural cycle or conventional IVF)
Exclusion Criteria
* Missing consent
* Female of the couple does not want to participate or missing consent
* Language barrier
* Medical freezing
* Social freezing
* Thawed cycles
* Genetic disorders
* Preimplantation genetic testing (PGT)
* Medication for chronic condition
* Surgery in the last 4 weeks
* Significant trauma in the last 90 days
* Severe reduced sperm quality
* Kryosperm
* Poor responder or expected poor response
18 Years
42 Years
ALL
No
Sponsors
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Janna Pape
OTHER
Responsible Party
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Janna Pape
Principal Investigator, Senior doctor, Janna Pape (MD)
Locations
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Inselspital Bern, Frauenklinik
Bern, , Switzerland
Countries
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Central Contacts
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Facility Contacts
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Michael von Wolff, Prof.
Role: primary
Janna Pape, Dr. med.
Role: backup
Other Identifiers
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KEK Bern 2022-00944
Identifier Type: -
Identifier Source: org_study_id