The Presence of Microbes in the Sperm and Their Impact on Sperm Capacitation and IVF Treatment
NCT ID: NCT02585297
Last Updated: 2015-10-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
200 participants
OBSERVATIONAL
2015-10-31
Brief Summary
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1. Finding the prevalence of bacteria of the sperm in an innovative and more accurate methode
2. Understanding the effect of microbes on the process of capacitation
3. The impact of microbes in the sperm on IVF success rate
4. Finding the incidence of vaginal bacteria and their relationship to bacteria of the sperm
5. The impact of vaginal flora on IVF success rate
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Detailed Description
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The control group consisting of 50 semen samples from men with no sperm problems and 50 vaginal samples from their partners.
The study group consisting of 50 semen samples from men with male fertility problems and 50 vaginal samples from their partners.
The semen taken from the remains after fertilization of the IVF laboratory. (Liquid otherwise routinely thrown).
Vaginal samples taken from women undergoing IVF treatment under anesthesia after informed consent.
Enrollment also collect the following data: age, race, chronic illnesses, past surgeries and former fertility treatments. Data will be collected through anamnesis of the patient or the medical file after consent.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Control- semen
Semen of fertile men
no intervention
Control- vaginal discharge
Vaginal discharge of partners of fertile men
no intervention
Case-semen
Semen of infertile men
no intervention
Case- vaginal discharge
Vaginal discharge of partners of infertile men
no intervention
Interventions
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no intervention
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
80 Years
ALL
Yes
Sponsors
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Meir Medical Center
OTHER
Responsible Party
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References
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Trussell JC. Optimal diagnosis and medical treatment of male infertility. Semin Reprod Med. 2013 Jul;31(4):235-6. doi: 10.1055/s-0033-1345269. Epub 2013 Jun 17. No abstract available.
Rittenberg V, El-Toukhy T. Medical treatment of male infertility. Hum Fertil (Camb). 2010 Dec;13(4):208-16. doi: 10.3109/14647273.2010.534833.
Diemer T, Huwe P, Ludwig M, Hauck EW, Weidner W. Urogenital infection and sperm motility. Andrologia. 2003 Oct;35(5):283-7.
Goldenberger D, Kunzli A, Vogt P, Zbinden R, Altwegg M. Molecular diagnosis of bacterial endocarditis by broad-range PCR amplification and direct sequencing. J Clin Microbiol. 1997 Nov;35(11):2733-9. doi: 10.1128/jcm.35.11.2733-2739.1997.
Akutsu T, Motani H, Watanabe K, Iwase H, Sakurada K. Detection of bacterial 16S ribosomal RNA genes for forensic identification of vaginal fluid. Leg Med (Tokyo). 2012 May;14(3):160-2. doi: 10.1016/j.legalmed.2012.01.005. Epub 2012 Feb 7.
Domes T, Lo KC, Grober ED, Mullen JB, Mazzulli T, Jarvi K. The incidence and effect of bacteriospermia and elevated seminal leukocytes on semen parameters. Fertil Steril. 2012 May;97(5):1050-5. doi: 10.1016/j.fertnstert.2012.01.124. Epub 2012 Feb 16.
Bacteriospermia and sperm quality in infertile male patient
De Francesco MA, Negrini R, Ravizzola G, Galli P, Manca N. Bacterial species present in the lower male genital tract: a five-year retrospective study. Eur J Contracept Reprod Health Care. 2011 Feb;16(1):47-53. doi: 10.3109/13625187.2010.533219. Epub 2010 Nov 23.
Hou D, Zhou X, Zhong X, Settles ML, Herring J, Wang L, Abdo Z, Forney LJ, Xu C. Microbiota of the seminal fluid from healthy and infertile men. Fertil Steril. 2013 Nov;100(5):1261-9. doi: 10.1016/j.fertnstert.2013.07.1991. Epub 2013 Aug 29.
Weng SL, Chiu CM, Lin FM, Huang WC, Liang C, Yang T, Yang TL, Liu CY, Wu WY, Chang YA, Chang TH, Huang HD. Bacterial communities in semen from men of infertile couples: metagenomic sequencing reveals relationships of seminal microbiota to semen quality. PLoS One. 2014 Oct 23;9(10):e110152. doi: 10.1371/journal.pone.0110152. eCollection 2014.
Other Identifiers
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Meir hospital
Identifier Type: -
Identifier Source: org_study_id
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