Advanced Sperm Selection in ICSI: A Comparative Study of PICSI and ZyMot
NCT ID: NCT07240779
Last Updated: 2025-11-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
300 participants
INTERVENTIONAL
2025-11-15
2026-02-28
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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ICSI group
Sperm selection performed using traditional methods
No interventions assigned to this group
: PICSI Group
* Sperm selection performed using the Physiological Intracytoplasmic Sperm Injection (PICSI) method.
* Hyaluronic acid-based selection to choose mature, DNA-intact sperm.
* Followed by standard ICSI procedure.
picsi dish
theses techniques to selection mature and lowest DNA fragmentation sperm for injection in oocyte
ZyMot Group
* Sperm selection performed using the ZyMot microfluidic device.
* Mimics natural sperm migration to isolate motile, morphologically normal sperm.
* Followed by standard ICSI procedure
picsi dish
theses techniques to selection mature and lowest DNA fragmentation sperm for injection in oocyte
Interventions
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picsi dish
theses techniques to selection mature and lowest DNA fragmentation sperm for injection in oocyte
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Body mass index (BMI) between 19 kg/m and 35 kg/m
* Normal Prolactin level.
* No other endocrinological abnormality including thyroid disorder or diabetes.
* With antimullerian hormone (AMH) at least 1.5 ng/ml, ), with normal progesterone level.
* Primary or secondary infertility at least of 2 years duration.
* No evidence of endometriosis.
* No other medical or surgical disease.
* The day of embryo freezing is the fifth day (day 5), and all patients who undergo the process of transferring frozen embryos.
* The endometrium thickness is between 8-14 mm on day of transfer.
Exclusion Criteria
* Women laparoscopically diagnosed to have endometriosis within the last 1 year.
* Male infertility factor with immotile sperm.
20 Years
39 Years
ALL
Yes
Sponsors
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Sunrise Fertility Center
OTHER
Responsible Party
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Principal Investigators
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Ayat samir kamel
Role: PRINCIPAL_INVESTIGATOR
Sunrise Fertility Center
Rafaat Gabre, phd
Role: STUDY_DIRECTOR
faculity of science, Cairo university
Omaima Idris, phd
Role: STUDY_DIRECTOR
faculity of medicien, cairo university
Abeer mohsen
Role: STUDY_CHAIR
faculity of science, cairo University
Ahmed Said
Role: STUDY_CHAIR
Faculty of Science, Al-Azhar University, Assiut
Central Contacts
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Other Identifiers
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PICSI-ZYMOT methods
Identifier Type: -
Identifier Source: org_study_id
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