Reproductive Outcomes After Intracytoplasmic Sperm Injection (ICSI) With Surgically Retrieved Sperm.
NCT ID: NCT06951061
Last Updated: 2025-04-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ACTIVE_NOT_RECRUITING
200000 participants
OBSERVATIONAL
2007-01-01
2027-05-30
Brief Summary
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Detailed Description
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The study has three main goals:
1. To compare reproductive outcomes following ICSI with SRS, ICSI with ejaculated sperm, and conventional IVF.
2. To investigate whether artificial intelligence (AI) and machine learning (ML) algorithms can predict cumulative reproductive outcomes, including results from both fresh and frozen embryo transfer cycles.
3. To evaluate how AI/ML-based models perform in comparison to traditional statistical methods in terms of accuracy and predictive value.
Method: National Population-Based Registry Study: This includes all IVF and ICSI treatments performed in Sweden from January 1, 2007, to December 31, 2023, using data from the Swedish National Quality Registry for Assisted Reproduction (Q-IVF). AI will be used to analyze large datasets, detect patterns, and help identify key factors-such as sperm source, number of retrieved oocytes, and patient characteristics-that may influence treatment success. This approach could lead to personalized treatment plans and better predictions of successful pregnancy outcomes.
Special attention is given to outcomes in children born after ICSI with surgically retrieved sperm, as these sperm may be less mature and carry a higher risk of genetic abnormalities. The findings are expected to provide valuable insights into the reproductive and long-term health outcomes of these treatments, ultimately helping to improve care and treatment strategies for infertile couples.
Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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IVF with ejaculated sperm
This group have gone through IVF with ejaculated sperm. Both fresh and frozen cycles are included.
IVF/ICSI
In vitro fertilization with or without ICSI with ejaculated and surgically retrieved sperm.
ICSI with ejaculated sperm
This group have gone through ICSI with ejaculated sperm. Both fresh and frozen cycles are included.
IVF/ICSI
In vitro fertilization with or without ICSI with ejaculated and surgically retrieved sperm.
ICSI with surgically retrieved sperm
This group have gone through ICSI with surgically retrieved sperm. Both fresh and frozen cycles are included.
IVF/ICSI
In vitro fertilization with or without ICSI with ejaculated and surgically retrieved sperm.
Interventions
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IVF/ICSI
In vitro fertilization with or without ICSI with ejaculated and surgically retrieved sperm.
Eligibility Criteria
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Inclusion Criteria
* IVF treatments will be identified from the National register Q-IVF.
Exclusion Criteria
* Children conceived through oocyte and sperm donation
18 Years
45 Years
ALL
No
Sponsors
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Göteborg University
OTHER
Uppsala University
OTHER
Karolinska Institutet
OTHER
Responsible Party
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Panagiotis Tsiartas
Associate Professor
Principal Investigators
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Panagiotis Tsiartas, Associate Professor
Role: PRINCIPAL_INVESTIGATOR
Karolinska Institutet
Locations
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Department of Clinical Science, Intervention and Technology, Division of Obstetrics and Gynaecology, Karolinska Institute
Stockholm, , Sweden
Countries
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Other Identifiers
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2025-00935-01
Identifier Type: -
Identifier Source: org_study_id
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