The Role of Hydration on Exercise Performance - ODIN

NCT ID: NCT02980939

Last Updated: 2017-05-31

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 11 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-11-30
• Study Completion Date: 2017-03-18

Brief Summary

During exercise in the heat, there is a need to replenish fluids in order to avoid dehydration and decrease the risk for heat illness. What drives this urge to drink is the thirst mechanism. Following ingestion of fluids, there is an inhibition of thirst before there is a replenishing of fluids. However, there is little scientific evidence of where thirst is inhibited, if this thirst inhibition is augmented by exercise and how thirst itself influence exercise performance. Further, during rehydration studies, it is very difficult to successfully blind a subject to their drinking/hydration protocol. Previous studies that have blinded a subject to their drinking have used various methods such as intravenous fluid administration and/or nasogastric tubes. Therefore, the purpose of this research is to examine the mechanistic roles thirst inhibition plays while exercising in the heat while undergoing intravenous fluid administration. Specific attention will be directed to the cardiovascular and thermoregulatory function of the individuals. All blood, cardiovascular, thermoregulatory, and perceptual measures are shown in the diagram below.

Conditions

Dehydration

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: PREVENTION
• Blinding Strategy: SINGLE

Study Groups

Euhydration - no thirst

Group Type: PLACEBO_COMPARATOR

iv fluid infusion

Intervention Type: OTHER

Intravenous isotonic saline infusion

Dehydration - no Thirst

Group Type: EXPERIMENTAL

iv fluid infusion

Intervention Type: OTHER

Intravenous isotonic saline infusion

Interventions

iv fluid infusion

Intravenous isotonic saline infusion

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Cycling Racing History category 3 or higher USA cycling certification
• maximal oxygen uptake >55 ml/kg/min

Exclusion Criteria

• History of heat stroke
• Renal, cardiovascular, metabolic diseases
• Regular medication

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

University of Arkansas, Fayetteville

OTHER

Sponsor Role: lead

Responsible Party

Stavros Kavouras

Associate Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Stavros A Kavouras, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Arkansas

Locations

University of Arkansas - HPER

Fayetteville, Arkansas, United States

Countries

United States

Other Identifiers

16-10-135

Identifier Type: -

Identifier Source: org_study_id