Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
55 participants
INTERVENTIONAL
2008-03-31
2013-09-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
DOUBLE
Study Groups
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Sodium nitrate
0.1 mmol NaNO3 / kg bodyweight / day for three days.
Glucose Uptake
Glucose uptake is measured by oral glucose tolerance test and euglycemic clamp
Resting metabolic rate
Resting metabolic rate is measured by indirect calorimetry after an over-night fast
Sodium Chloride
0.1 mmol NaCl / kg bodyweight / day for three days.
Glucose Uptake
Glucose uptake is measured by oral glucose tolerance test and euglycemic clamp
Resting metabolic rate
Resting metabolic rate is measured by indirect calorimetry after an over-night fast
Sodium nitrite infusion
Sodium nitrite (NaNO2) at a rate of 1, 10 and 100 nmol kg-1 min-1 (10 minutes per dose) was infused intravenously.
Nitrite infusion
Sodium nitrite or saline was infused at escalating doses at a rate of 1, 10 or 100 nmol kg-1 min-1 (10 minutes per dose) in a randomized, double blinded cross-over fashion
Saline infusion
Saline at a rate corresponding to 1, 10 and 100 nmol NaCl kg-1 min-1 (10 minutes per dose) was infused intravenously.
Nitrite infusion
Sodium nitrite or saline was infused at escalating doses at a rate of 1, 10 or 100 nmol kg-1 min-1 (10 minutes per dose) in a randomized, double blinded cross-over fashion
Interventions
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Glucose Uptake
Glucose uptake is measured by oral glucose tolerance test and euglycemic clamp
Resting metabolic rate
Resting metabolic rate is measured by indirect calorimetry after an over-night fast
Nitrite infusion
Sodium nitrite or saline was infused at escalating doses at a rate of 1, 10 or 100 nmol kg-1 min-1 (10 minutes per dose) in a randomized, double blinded cross-over fashion
Eligibility Criteria
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Inclusion Criteria
18 Years
50 Years
ALL
Yes
Sponsors
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The Swedish Research Council
OTHER_GOV
Swedish Heart Lung Foundation
OTHER
Karolinska Institutet
OTHER
Responsible Party
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Eddie Weitzberg
Professor
Locations
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Karolinska Institutet
Stockholm, , Sweden
Countries
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References
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Larsen FJ, Schiffer TA, Borniquel S, Sahlin K, Ekblom B, Lundberg JO, Weitzberg E. Dietary inorganic nitrate improves mitochondrial efficiency in humans. Cell Metab. 2011 Feb 2;13(2):149-59. doi: 10.1016/j.cmet.2011.01.004.
Other Identifiers
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JETF-6996-NO
Identifier Type: -
Identifier Source: org_study_id
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