Dynamic Alterations of Th2/Th1 With New Onset of Community-acquired Severe Sepsis Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

85 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-09-30

Study Completion Date

2018-08-01

Brief Summary

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To evaluate the dynamic alterations of Th2/Th1 for the prediction of clinical immunity and how it was related to 28 day-prognosis and ICU-acquired infections among critically ill patients of community-acquired severe sepsis with new onset.

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Detailed Description

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Conditions

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Sepsis

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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Comunity-acquired severe sepsis patients

Patients with new-onset community-acquired severe sepsis within 24h without confounding factors in immune status

No interventions assigned to this group

Non-severe sepsis patients

Patients between 18 and 90 years of age and be admitted to the ICU without a diagnosis of severe sepsis.

No interventions assigned to this group

Healthy controls

Heathy vonlunteers between 18 and 90 years of age.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* at least 18 years of age and no more than 90 years of age
* sepsis was defined according to consensus criteria
* diagnosis of sepsis and complicatied with organ dysfunction no longer than 48 h
* provided written informed consent.

* at least 18 years of age and no more than 90 years of age
* without diagnosis of sepsis and admitted to ICU
* provided written informed consent.

* at least 18 years of age and no more than 90 years of age
* provided written informed consent.

Exclusion Criteria

* diagnosis of hematological,immunological disease or cancer
* treatment with chemotherapy agents or corticosteroids within 6 months prior to or during the hospitalization

For non-severe sepsis ICU control group:

* diagnosis of hematological,immunological disease or cancer
* treatment with chemotherapy agents or corticosteroids within 6 months prior to or during the hospitalization

For healthy control group:

* diagnosis of hematological,immunological disease or cancer
* treatment with chemotherapy agents or corticosteroids within 6 months prior to enrollment

Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes