Immune Function Monitoring and Immunotherapy in Sepsis

NCT ID: NCT04903405

Last Updated: 2021-05-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

5000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-06-01

Study Completion Date

2021-07-30

Brief Summary

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At present, the clinical studies of various anti-inflammatory drugs and immune-enhancing drugs show that immunotherapy will bring new hope for the treatment of sepsis. In order to further understand the current status of immunotherapy in China, this study aims to understand the current status and standardization of the use of sepsis immunosurveillance and immunotherapy in hospitals through a cross-sectional survey.

Detailed Description

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Conditions

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Sepsis Septic Shock

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Sepsis

No intervention

Intervention Type OTHER

No intervention is involved in this study

Interventions

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No intervention

No intervention is involved in this study

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients with sepsis or septic shock according to Sepsis 3.0

Exclusion Criteria

* None
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sun Yat-sen University

OTHER

Sponsor Role lead

Responsible Party

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Wu Jianfeng

chief physician

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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Jianfeng Wu

Role: CONTACT

020-87755766-8453

Fei Pei

Role: CONTACT

020-87755766-8453

References

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Pei F, Zhang GR, Zhou LX, Liu JY, Ma G, Kou QY, He ZJ, Chen MY, Nie Y, Wu JF, Guan XD; China Critical Care Immunotherapy Research Group. Early Immunoparalysis Was Associated with Poor Prognosis in Elderly Patients with Sepsis: Secondary Analysis of the ETASS Study. Infect Drug Resist. 2020 Jun 30;13:2053-2061. doi: 10.2147/IDR.S246513. eCollection 2020.

Reference Type BACKGROUND
PMID: 32636658 (View on PubMed)

Wu J, Zhou L, Liu J, Ma G, Kou Q, He Z, Chen J, Ou-Yang B, Chen M, Li Y, Wu X, Gu B, Chen L, Zou Z, Qiang X, Chen Y, Lin A, Zhang G, Guan X. The efficacy of thymosin alpha 1 for severe sepsis (ETASS): a multicenter, single-blind, randomized and controlled trial. Crit Care. 2013 Jan 17;17(1):R8. doi: 10.1186/cc11932.

Reference Type BACKGROUND
PMID: 23327199 (View on PubMed)

Wu JF, Ma J, Chen J, Ou-Yang B, Chen MY, Li LF, Liu YJ, Lin AH, Guan XD. Changes of monocyte human leukocyte antigen-DR expression as a reliable predictor of mortality in severe sepsis. Crit Care. 2011;15(5):R220. doi: 10.1186/cc10457. Epub 2011 Sep 20.

Reference Type BACKGROUND
PMID: 21933399 (View on PubMed)

Other Identifiers

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IMITS

Identifier Type: -

Identifier Source: org_study_id

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