Dissecting How Peripheral Lymphocytes Are Lost During Sepsis
NCT ID: NCT03289312
Last Updated: 2017-12-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
54 participants
OBSERVATIONAL
2018-01-11
2018-12-31
Brief Summary
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Detailed Description
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①Demography data，diagnosis, admission source, infection source, APACHE II,SOFA scores;②Endotoxin levels and PaO2 measured;③Immune and systemic inflammatory indicators：T, RR, WBC, ALC, etc.;④Complicated organs dysfunctions: duration and therapy;⑤Incidence of ICU-acquired infection and prognosis.The blood samples were collected for apoptosis,necrosis,autophagy,pyroptosis measurements.The aim of this study is to investigate how peripheal lymphocyte loss relates to outcome and the mechanisms of peripheal lymphocyte loss in different condition.
Conditions
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Keywords
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Sepsis
Diagnosis of new onset sepsis within 24h without history of tumor, hematological or immunological disease, and treatment with chemotherapy agents or corticosteroids within 6 months prior to or during the hospitalization.
No interventions assigned to this group
Health control
Health vonlunteers
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
90 Years
ALL
Yes
Sponsors
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Southeast University, China
OTHER
Responsible Party
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Jianfeng Xie
Southeast University, China
Locations
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Zhongda Hospital
Nanjing, Jiangsu, China
Countries
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Central Contacts
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Other Identifiers
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2017ZDSYSLLoss
Identifier Type: -
Identifier Source: org_study_id