Genomics in Infection and Sepsis to Predict Organ Dysfunction and Outcomes in Sepsis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

120 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-12-12

Study Completion Date

2023-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This is a prospective cohort study using gene expression to study patients with infection and sepsis from pneumonia.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

A Prospective Observational Study of Sepsis

NCT05309889

Sepsis

UNKNOWN

Study on the Construction and Application of Early Warning Model of Sepsis in Critically Ill Patients

NCT06904001

Sepsis Sepsis and Septic Shock Infection

ENROLLING_BY_INVITATION

Regulatory Network and Diagnostic Value of Key Autophagy-related Genes in Sepsis

NCT05524376

Sepsis Autophagy

UNKNOWN

Association Between cd163 Gene Polymorphisms and Sepsis Among Chinese Han Population

NCT01504243

Sepsis

UNKNOWN

Establishment of Early Diagnosis and Monitoring Model for Sepsis Patients

NCT04974411

Sepsis

UNKNOWN

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This is a prospective cohort study using single cell transcriptomic profiling and plasma DNA tissue mapping on patients with pneumonia with or without sepsis. The major application of the investigator's study would be the discovery of gene expressions in different leucocytes and plasma DNA associated with each type of organ dysfunction in sepsis. These include cardiovascular, respiratory, hepatic, renal, neurological and haematological dysfunction. This would help prediction, diagnosis and development of therapies to treat sepsis. Leucocyte single cell transcriptome and plasma DNA tissue mapping may addresses the limitations of current evidence in 3 ways: (1) differentiate patients with uncomplicated pneumonia versus pneumonia with associated sepsis, (2) correlation with types and severity of organ dysfunction and (3) identifying molecular phenotypes of sepsis.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Sepsis Infection Pneumonia

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

pneumonia without sepsis

adult patients with community acquired pneumonia change in SOFA score \<2 (other than respiratory component)

No interventions assigned to this group

pneumonia with sepsis

adult patients with community acquired pneumonia change in SOFA score greater or equal to 2 (other than respiratory component)

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

All of the following:

* newly admitted adult patients (≥ 18 years old)
* suspected community acquired pneumonia (CAP)
* compatible history of either sputum or cough or fever or rigors within 1 week
* chest X-ray infiltrates

Exclusion Criteria

Any of the following:

* chest symptoms not solely accounted by pneumonia (cardiac failure, non cardiogenic pulmonary oedema, suspected pulmonary embolism, suspected secondary acute respiratory distress syndrome)
* immunosuppression
* current malignancy
* blood samples for gene expression could not be taken within 24 hours of admission
* prisoner/cogni tive impairment
* blood transfusion within 1 month
* hospitalization within 1 month

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No