Study on the Role of Gamma Delta T Cells in Sepsis Immunosuppression and Its Molecular Mechanism

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

84 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-05-31

Study Completion Date

2015-05-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of the study is to evaluate the status and function of gamma delta T cells in peripheral blood of sepsis patients.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Study on Antigen-presenting Function of Gamma Delta T Cells in Sepsis and Its Molecular Mechanisms

NCT03379896

Sepsis Antigen-presenting Function γδ T Cells

UNKNOWN

The Changes of CD4+T Lymphocyte Subsets in Septic Patients

NCT01494389

Sepsis SIRS(Systemic Inflammatory Response Syndrome)

UNKNOWN

Dissecting How Peripheral Lymphocytes Are Lost During Sepsis

NCT03289312

Sepsis

UNKNOWN

Causes and Factors Associated With Outcomes in Community-acquired Sepsis and Severe Sepsis in Northeast Thailand

NCT02217592

Sepsis Severe Sepsis

COMPLETED

The Predictive Value of Hepatocyte Growth Factor and Soluble Receptor s-Met in Sepsis

NCT03340649

Sepsis

UNKNOWN

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Sepsis therapy is a prominent problem of the modern critical care medicine,and improving the level of sepsis treatment by immune intervention measures is a hot research topic with close attention.Gamma delta T cells is considered as one new T lymphocyte subset in recent years,which playing an important role in resistance to infection,anti-tumor and immune regulating function in the body.First,we played attention to the status and function of gamma delta T cells in peripheral blood of sepsis patients including differentiation marker,subtype and production of related cytokine,and then the molecular mechanism of insufficient gamma delta T cells.At the same time the responsibility of gamma delta T cells of sepsis patients to certain bacteria and viral antigen and the regulation of gamma delta T cells on other natural immune cells including NK cells and mononuclear cells were studied to identify the status and role gamma delta T cells in sepsis immunosuppression by culture in vitro.Further we studied the effect of specific stimulants on proliferation and activation of gamma delta T cells in patients with sepsis and also anti-infection acquired by gamma delta T cells,expecting as an entry point to explore new treatment strategy to sepsis.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Sepsis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

severe sepsis and septic shock

patients were diagnosed severe sepsis or septic shock

No interventions assigned to this group

patient control

Patients after elective surgeries presented with SIRS but without sepsis

No interventions assigned to this group

volunteer

Health persons

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* clinical symptoms of severe sepsis and septic shock
* age over 18 years

Exclusion Criteria

* preexisting autoimmune disease
* patients received immuno-suppressive treatment in the previous 6 months
* patients with chronic infection,e.g.tuberculosis,hepatitis or HIV infection,etc.
* pregnancy

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes