Inflammatory Mediators in Early Sepsis

NCT ID: NCT02692118

Last Updated: 2021-06-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-12-31

Study Completion Date

2022-09-30

Brief Summary

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Sepsis is still a challenge for clinicians since the detailed pathomechanism are still unknown and until now early markers for sepsis are not defined yet. Immunological pathways and new mediators defined in animal models are not yet investigated in patients with sepsis. Therefore the investigators will measure new mediators in patients with septic shock.

Detailed Description

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Semaphorins 1 to 7 will be determined in Blood of patients with early septic shock. Concentration will be compared with blood concentration of postoperative patients suffering systemic inflammatory response syndrome (SIRS).

Conditions

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Inflammation

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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sepsis

Patients with septic shock admitted to ICU

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Septic Shock

Exclusion Criteria

* Age \< 18 \> 85
* no consent of caregiver
* Trauma patients
* Burn patients
* Immunosuppression
* Pregnancy
* HIV- hepatitis infection
Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital Tuebingen

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Peter Rosenberger, MD

Role: PRINCIPAL_INVESTIGATOR

University Hospital Tuebingen

Locations

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University Hospital Tuebingen

Tübingen, , Germany

Site Status RECRUITING

Countries

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Germany

Central Contacts

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Peter Rosenberger, MD

Role: CONTACT

+49(0)7071298 ext. 6622

Helene A Haeberle, MD

Role: CONTACT

+49(0)7071298 ext. 6622

Facility Contacts

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Peter Rosenberger, MD

Role: primary

Helene A Haeberle, MD

Role: backup

References

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Granja T, Kohler D, Tang L, Burkard P, Eggstein C, Hemmen K, Heinze KG, Heck-Swain KL, Koeppen M, Gunther S, Blaha M, Magunia H, Bamberg M, Konrad F, Ngamsri KC, Fuhr A, Keller M, Bernard AM, Haeberle HA, Bakchoul T, Zarbock A, Nieswandt B, Rosenberger P. Semaphorin 7A coordinates neutrophil response during pulmonary inflammation and sepsis. Blood Adv. 2024 Jun 11;8(11):2660-2674. doi: 10.1182/bloodadvances.2023011778.

Reference Type DERIVED
PMID: 38489236 (View on PubMed)

Other Identifiers

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AnaTubingen

Identifier Type: -

Identifier Source: org_study_id

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