Validation of Progranulin as a Biomarker for Sepsis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

556 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-04-30

Study Completion Date

2019-06-30

Brief Summary

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Progranulin blood concentrations in patients with sepsis will be analysed in relation to disease status in order to validate progranulin as a biomarker for sepsis. Patients undergoing cardiac surgery will serve as controls.

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Detailed Description

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Single nucleotide polymorphisms with known effects on Progranulin plasma concentrations will be assessed in a separate analysis. Expression levels of microRNAs isolated from plasma, circulating exosomes and blood cells will be determined by next-generation sequencing to characterize epigenetic influences on progranulin plasma levels.

Conditions

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Sepsis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Sepsis

Patients with sepsis

No interventions assigned to this group

Cardiac Surgery

Patients undergoing cardiac surgery

No interventions assigned to this group

Healthy controls

Normal individuals

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Sepsis or Septic Shock defined according to SEPSIS-3 criteria - Age \> 18 years

Exclusion Criteria

* No informed consent
* Age \< 18 years
* Pregnancy
* Immunosuppression (including transplantation)
* Charlson Comorbidity Index \> 0 (healthy volunteers)

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes