Olfactory and Visual Perception in Depressed Patients

NCT ID: NCT02857088

Last Updated: 2016-08-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

3 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-02-28

Study Completion Date

2016-04-30

Brief Summary

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The study aimed to determine the emotional reactivity of depressed patients to visual and olfactory stimuli in comparison with healthy volunteers.

Detailed Description

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Conditions

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Depression

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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depressed patients

patient with a current unipolar major depressive disorder intervention: olfactory assessment, image visualization and psychophysiological assessment

Group Type EXPERIMENTAL

olfactory assessment

Intervention Type BEHAVIORAL

determination of olfactory sensitivity through olfactory threshold assessment (butanol) determination of hedonicity and intensity of 16 usual odors

image visualization

Intervention Type BEHAVIORAL

20 images (from the IAPS-international affective picture systems) are presented to the subject. He has to determine the hedonicity of each picture.

psychophysiological assessment

Intervention Type BEHAVIORAL

during the olfaction assessment and the image visualization, skin conductance reactivity (SCR) is recorded to assess unconscious emotional reactivity

non depressed subject

subject without a current unipolar major depressive disorder intervention: olfactory assessment, image visualization and psychophysiological assessment

Group Type EXPERIMENTAL

olfactory assessment

Intervention Type BEHAVIORAL

determination of olfactory sensitivity through olfactory threshold assessment (butanol) determination of hedonicity and intensity of 16 usual odors

image visualization

Intervention Type BEHAVIORAL

20 images (from the IAPS-international affective picture systems) are presented to the subject. He has to determine the hedonicity of each picture.

psychophysiological assessment

Intervention Type BEHAVIORAL

during the olfaction assessment and the image visualization, skin conductance reactivity (SCR) is recorded to assess unconscious emotional reactivity

Interventions

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olfactory assessment

determination of olfactory sensitivity through olfactory threshold assessment (butanol) determination of hedonicity and intensity of 16 usual odors

Intervention Type BEHAVIORAL

image visualization

20 images (from the IAPS-international affective picture systems) are presented to the subject. He has to determine the hedonicity of each picture.

Intervention Type BEHAVIORAL

psychophysiological assessment

during the olfaction assessment and the image visualization, skin conductance reactivity (SCR) is recorded to assess unconscious emotional reactivity

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* no cognitive impairment that could prevent instruction comprehension
* no more than 10 cigarettes/day
* signed informed consent
* group 1: current major depressive disorder
* group 2: no current major depressive disorder

Exclusion Criteria

* pregnancy
* visual impairment
* olfactory impairment
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Centre Hospitalier Universitaire de Besancon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Sylvie Nezelof, MD PhD

Role: PRINCIPAL_INVESTIGATOR

Centre Hospitalier Universitaire de Besancon

Locations

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CHU Besancon

Besançon, Doubs, France

Site Status

Countries

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France

Other Identifiers

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P/2011/126

Identifier Type: -

Identifier Source: org_study_id

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