Behavioral Processes Underlying Reward Processing in Depression

NCT ID: NCT00205933

Last Updated: 2007-12-06

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 78 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2004-04-30
• Study Completion Date: 2007-06-30

Brief Summary

The purpose of this project is to use behavioral techniques to investigate emotional processing in subjects with major depression and healthy comparison subjects.

Detailed Description

A promising strategy for parsing the heterogeneity of Major Depressive Disorder is to identify phenotypes characterized by reliable functional abnormalities. Anhedonia, the lack of reactivity to pleasurable stimuli, is considered a trait marker for depression. Using an objective behavioral task this project aims to investigate hedonic capacity in subjects meeting a DSM-IV diagnosis of Major Depressive Disorder.

Conditions

Major Depressive Disorder; Bipolar Disorder

Keywords

Depression; Bipolar Disorder; Reward Processing

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: CROSS_SECTIONAL

Eligibility Criteria

Inclusion Criteria

Depressed participants:

• Right-handed
• DSM-IV diagnosis of MDD
• Score of at least 17 on the 21-item HAM-D scale
• Absence of any psychotropic medications for at least 2 weeks (6 months for dopaminergic drugs (including methylphenidate), 6 weeks for fluoxetine, and 4 weeks for neuroleptics and benzodiazepines because of longer half-lives.)
• No current or past history of MDD with psychotic features
• Absence of any other Axis I or Axis II diagnosis (Including bipolar disorder and current or lifetime history of alcohol or substance abuse or dependence.) Particularly, subjects with a history of alcoholism and substance abuse will be excluded, since dopaminergic alterations have been reported in these conditions. Exclusion of patients with comorbid Axis I or Axis II diagnoses will be necessary as evidence exists of alteration in dopamine receptor density in detached personality and social phobia. The alteration of dopamine in the brain may in turn alter behavior.
• Absence of significant medical conditions
• Absence of ECT in the previous 6 months
• Ability to provide informed consent/authorization

Bipolar participants:

• Both genders and all ethnic origins
• Age between 18 and 64
• Right-handed
• DSM-IV diagnosis of Bipolar Disorder I or II
• Score of at least 17 on the 21-item Hamilton Depression Rating Scale (HAM-D)
• Absence of any psychotropic medications for at least 2 weeks (6 months for dopaminergic drugs (including methylphenidate), 6 weeks for fluoxetine, and 4 weeks for neuroleptics and benzodiazepines because of longer half-lives.)
• No current or past history of MDD with psychotic features
• Absence of any other Axis I or Axis II diagnosis (Including current or lifetime history of alcohol or substance abuse or dependence.) Particularly, subjects with a history of alcoholism and substance abuse will be excluded.
• Absence of significant medical conditions
• Absence of ECT in the previous 6 months
• Ability to provide informed consent/authorization

Control Participants:

• Right-handed
• Absence of medical, neurological, and psychiatric illness (including alcohol and substance abuse), as assessed by the SCID
• Absence of any medications for at least 2 weeks
• Informed consent/authorization

Exclusion Criteria

• Left-handed/ambidextrous
• Evidence of neurological illness
• Current alcohol or substance abuse
• Serious suicide or homicide risk

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 64 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Massachusetts General Hospital

OTHER

Sponsor Role: collaborator

Affective Neuroscience Laboratory

OTHER

Sponsor Role: lead

Responsible Party

Harvard University

Principal Investigators

Diego A Pizzagalli, PhD

Role: PRINCIPAL_INVESTIGATOR

Harvard University

Locations

The Depression Clinical and Research Program, Massachusetts General Hospital

Boston, Massachusetts, United States

Affective Neuroscience Laboratory, Department of Psychology, Harvard University

Cambridge, Massachusetts, United States

Countries

United States

Other Identifiers

2003-P-000994

Identifier Type: -

Identifier Source: org_study_id