Stress Sensitivity and Reward Responsivity in Depression

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

219 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-07-31

Study Completion Date

2018-12-31

Brief Summary

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The goal of this project is to learn more about the different ways in which people process information that is stressful and rewarding, and how abnormalities in these two processes are related to depression.

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Detailed Description

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Participants will participate in two 3-hour sessions separated by a week at Providence Care, Mental Health Services, and a third, 1.5-hour session at the Queen's MRI Facility. At the first session participants will complete a packet of questionnaires about their mood and take part in an interview about their mood, medications, drug use, and any other symptoms, as well as an interview about their relationships with their parents and any experiences of abuse. At the second session participants will participate in a stress test, which involves giving a speech to a panel. The investigators will also collect saliva samples to look at stress hormones. Participants will also complete a task on the computer that involves looking at cartoon faces and making decisions about them. At the third session, the investigators take images of of participant's brain using a magnetic resonance scanner.

Participants are invited to participate in a 6-month follow-up for this study, which would involve the same procedure as outline above.

Conditions

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Depressed

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Depressed Participants

No intervention

No interventions assigned to this group

Healthy Control Participants

No intervention

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Outpatients aged 18-65
* Currently suffering from unipolar depression
* Fluency in English, sufficient to complete the interviews and self-report questionnaires

* Adults aged 18-65
* No history of Axis I disorders according to DSM-IV-TR criteria, as determined by the SCID
* No first-degree relatives diagnosed with bipolar disorder
* Fluency in English, sufficient to complete the interviews and self-report questionnaires

Exclusion Criteria

* Clinical diagnosis of bipolar disorder, psychotic disorders, current alcohol/substance dependence, or significant medical comorbidity
* Treatment-resistant (defined as failing more than 3 trials of anti-depressant medication)
* History of neurological insult (e.g., concussion), neurological disease, seizure disorder
* Smokers
* Pregnant women
* Endocrine disorders
* High suicidal risk, defined by clinician judgement

For Healthy Control Participants:

* History of neurological insult (e.g., concussion), neurological disease, seizure disorder
* Smokers
* Pregnant women
* Endocrine disorders

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes