Comparative Study of Physiological and Cerebrovascular Reactivity in Depression, at the Three Phases of Emotion
NCT ID: NCT02026622
Last Updated: 2025-12-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
76 participants
INTERVENTIONAL
2013-02-28
2015-08-31
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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3 groups of subjects
3 groups: depressive subjects, subjects remitted from depression and control subjects, with the same interventions.
psychometric tests, MRI, transcranial doppler and TPI, explicitative interview
psychometric tests
NEO-PI, MADRS, MINI depression, MMSE, STAI-E, ERD, Anhedonia
MRI
ASL, rest f-MRI, FLAIR, white matter hyper intensities load
transcranial doppler and TPI
transcranial doppler TPI
explicitative interview
Interventions
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psychometric tests
NEO-PI, MADRS, MINI depression, MMSE, STAI-E, ERD, Anhedonia
MRI
ASL, rest f-MRI, FLAIR, white matter hyper intensities load
transcranial doppler and TPI
transcranial doppler TPI
explicitative interview
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Informed consent form signed
* Affiliated to a medical insurance
* visual and hearing abilities suitable for exams
* for the depressive group (group D): major depressive disorder according to the DSM-IV criteria as evaluated by the MINI test and MADRS score ≥22
* for the depressive patients in remission's group (group R) : matched on age, at least 1 history of major depressive disorder in the last 10 years and solved for more than 6 months, and MADRS score \< 9
* for the control subjects (group T) : matched on age, no psychiatric history, MADRS score \< 9
Exclusion Criteria
* current betablockers or neuroleptics treatment
* any current organic unstable pathology
* history of serious cardiovascular disease (coronary syndrome, cardiac arrythmia, etc.)
* smoking \> 10 PY
* history of serious neurologic disease (stroke, cerebral tumour, serious cranial trauma, headache, ...)
* contra-indication to MRI
* uncorrected vision or audition troubles
* patient under juridic protection
* pregnancy, lactating or female without reliable contraception
18 Years
55 Years
FEMALE
Yes
Sponsors
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University Hospital, Tours
OTHER
Responsible Party
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Locations
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University Hospital of Tours
Tours, , France
Countries
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References
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Siragusa MA, Rufin T, Courtois R, Belzung C, Andersson F, Brizard B, Dujardin PA, Cottier JP, Patat F, Remenieras JP, Gissot V, El-Hage W, Camus V, Desmidt T. Left amygdala volume and brain tissue pulsatility are associated with neuroticism: an MRI and ultrasound study. Brain Imaging Behav. 2021 Jun;15(3):1499-1507. doi: 10.1007/s11682-020-00348-w.
Other Identifiers
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PHAO 2012 - TD / EMPHILINE
Identifier Type: -
Identifier Source: org_study_id