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Advanced MRI in Major Depression

NCT ID: NCT00613912

Last Updated: 2011-11-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

49 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-03-31

Study Completion Date

2011-06-30

Brief Summary

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Depression is the most common psychiatric disorder.

* 3-5% of a given population has major depression.
* Less than 50% of the depressed in Denmark are diagnosed with major depression.
* 25-50% of the depressed have a relative with major depression-underlying brain pathology?

The purpose of this study is to use MRI to evaluate cerebral morphology and function in ambulant patients with major depression

Detailed Description

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Previous studies within major depression, have often included hospitalized patients with severe symptoms and imaging have been performed with PET and SPECT, which uses ionizing radiation. This study focus on ambulant patients(with or without medication/ECT treatment), to find patients in an earlier stage. Cerebral perfusion with the MR sequence Arterial Spin Labelling, concentrations of different metabolites with MR spectroscopy and brain volumetry with BRAVO 3D T1 ax will be performed.

MR protocol: T2 sag, T2 FLAIR ax, ASL ax, MRS and 3D T1 ax. Scan time 45 min.

Conditions

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Depressive Disorder, Major

Keywords

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Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Perfusion, brain

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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A

Ambulant patients with major depression

Magnetic Resonance Imaging

Intervention Type OTHER

* Morphological sequences
* Arterial Spin Labelling (Perfusion)
* Spectroscopy: anterior cingulate cortex Naa, Cho, Cr, Myo-inositol, glutamate TE 30 Reference voxel in Parietal white matter

Interventions

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Magnetic Resonance Imaging

* Morphological sequences
* Arterial Spin Labelling (Perfusion)
* Spectroscopy: anterior cingulate cortex Naa, Cho, Cr, Myo-inositol, glutamate TE 30 Reference voxel in Parietal white matter

Intervention Type OTHER

Other Intervention Names

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3 Tesla GE Scanner HDx

Eligibility Criteria

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Inclusion Criteria

* Patients who fulfil ICD-10´s criteria for major depression, found within the ambulant psychiatric sector and who has a HAM-D ≥ 18

Exclusion Criteria

* If the patient has pacemaker or other magnetic devices
* Pregnancy
* Has had an operation in the brain
* bipolar disorder
Minimum Eligible Age

20 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Aarhus

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Elna-Marie B Larsson, Professor

Role: PRINCIPAL_INVESTIGATOR

Uppsala University Hospital

Locations

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Aalborg Hospital / Aarhus University Hospital

Aalborg, Jutland, Denmark

Site Status

Countries

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Denmark

Other Identifiers

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AUFF-2005-740-004

Identifier Type: -

Identifier Source: org_study_id