Neuronal Responses to Social Feedback in Major Depressive Disorder

NCT ID: NCT02180607

Last Updated: 2015-05-28

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 58 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2013-10-31
• Study Completion Date: 2014-10-31

Brief Summary

The overall goal of the proposed project is to investigate the neuronal pathways regulating the effects of social acceptance and rejection in healthy controls and patients with Major Depressive Disorder (MDD). Social acceptance and rejection are defined as the explicit declaration that an individual is liked or not liked. Social acceptance can boost one's self-esteem and mood, whereas rejection can lower them. The neurological relationship between social acceptance/rejection and depressive symptoms is not known. Using functional magnetic resonance imaging (fMRI), it is hypothesized that social feedback will activate a specific interconnected neuronal pathway involved in social separation and reward. Executive functioning and response to monetary reward will also be assessed during fMRI using two additional tasks (monetary incentive delay, parametric go no-go) to determine how these cognitive brain functions regulate responses to social feedback.

Conditions

Major Depressive Disorder

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Healthy Controls

Response to social feedback, monetary incentive delay, and go/no-go tasks

No interventions assigned to this group

MDD patients

Response to social feedback, monetary incentive delay, and go/no-go tasks

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Men and women between 18 and 55 years of age
• No use of psychotropic medications in the past 4 weeks
• No regular tobacco use, and who are able to make decisions for his or her self -Patients who meet criteria for (DSM-IV) Major Depressive Disorder or Depressive Disorder Not Otherwise Specified, with Hamilton Depression Rating Scale scores ≥ 10, and may be on monotherapy (treatment for MDD with a single SSRI)
• MDD patients will be matched with healthy controls for age and education.

Exclusion Criteria

• No serious medical illnesses or major physiological disturbance during the past three months (e.g., serious infections or pregnancy) or anemia Any other Axis I psychiatric disorder
• History of DSM-IV alcohol or drug dependence within the past 5 years
• Drug or alcohol abuse in the past 2 years or a CAGE Alcohol Screening Inventory score of >3
• Regular alcohol use during the past 6 months equal to or greater than 16 cans of beer per week or equivalent; use of street drugs during the past 2 years
• Regular tobacco use, since nicotine stimulates cortisol secretion even in smokers;
• Major chronobiological disruption or phase shift during the preceding month (e.g., total sleep deprivation, reversal of sleep-wake cycles or trans-meridian travel)
• Childbirth or miscarriage within 6 months
• Breastfeeding within 6 months of recruitment
• Progestin-only birth controls (e.g., Cerazette, Ovrette)
• No contraindications to MRI scan including neurostimulators, metal in the body, weight over 250 pounds, and girth size incompatible for MRI scanner bore
• No non-right-handed subjects
• For healthy controls, subjects will have no history of psychiatric problems in themselves or any first-degree relatives

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 55 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

National Institute of Mental Health (NIMH)

NIH

Sponsor Role: collaborator

University of Michigan

OTHER

Sponsor Role: lead

Responsible Party

David Hsu

Research Assistant Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

David T Hsu, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

University of Michigan

Locations

University of Michigan

Ann Arbor, Michigan, United States

Countries

United States

Other Identifiers

K01MH085035

Identifier Type: NIH

Identifier Source: org_study_id

View Link