Using Neuroimaging to Investigate Major Depressive Disorder

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

14 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-05-31

Study Completion Date

2011-01-20

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this neuroimaging study is to investigate the brain correlates of Major Depressive Disorder with anxiety symptoms as well as potentially identify predictors of treatment outcome.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Neuro MRI Biomarkers for Treatment Navigation in Depression

NCT05701267

Depressive Disorder, Major

COMPLETED

DPA-714 and FDG PET/MRI in Depression

NCT06565936

Depression

RECRUITING NA

Probing Prefrontal Cortex Hemodynamic Alterations for Major Depression Disorder

NCT03595020

Depressive Disorder, Major

UNKNOWN

The Relations Among Endotoxin, Inflammatory Cytokines, Cognitive Markers and Brain MRI Changes in Subjects With Depressive Disorder

NCT06203015

Major Depressive Disorder Inflammation Cognitive Dysfunction +3 more

RECRUITING

Brain Inflammation in Major Depressive Disorder Background

NCT01851356

Major Depression

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The purpose of this study is to test whether the structural and functional connectivity between the dorso-lateral prefrontal cortex (DLPFC) and amygdala will decline as symptoms of co-morbid anxiety (Anxiety Factor Score) increase in patients with MDD. This decrease in connectivity will also account for decrease in treatment response. The structural connectivity will be assessed using Diffusion Tensor Imaging (DTI) and the functional connectivity will be assessed using resting state BOLD fMRI.We propose to use the fMRI and DTI to identify biological markers that are associated with treatment response in a cohort of patients with a spectrum of Anxiety Factor Scores.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Major Depressive Disorder Depression Anxiety

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

MDD

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Competent to give informed consent
* Diagnosis of Major Depressive Disorder
* Males and females
* Ages 18-50 years old
* All races and ethnicities
* Able to read, speak, and understand English\*

Exclusion Criteria

* History of psychiatric illness except Major Depressive Disorder, Generalized Anxiety Disorder, Social Phobia, or Specific Phobia
* Alcohol or substance abuse within the last 6 months or alcohol or substance dependence within the last year
* Diagnosis of an organic brain disease
* Serious unstable medical illness
* History of serious head injury
* Unsafe or unable to have an MRI or previous inability to tolerate MRI
* Pregnancy or breast feeding

Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No