Magnetic Resonance Imaging Study of Geriatric Depression

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

43 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-11-30

Study Completion Date

2008-08-31

Brief Summary

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The purpose of this study was to use Magnetic Resonance Images to further our understanding of predictors and markers of treatment response and non-response in geriatric depression. We hypothesized that concentrations of high energy metabolites would be lower in depressed elderly compared to non-depressed.

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Detailed Description

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Conditions

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Major Depressive Disorder

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Healthy Controls

Healthy Controls undergo MRI and neuropsychological testing

Group Type NO_INTERVENTION

No interventions assigned to this group

Depressed

Depressed subjects receive experimental drug

Group Type EXPERIMENTAL

Sertraline

Intervention Type DRUG

Oral Sertraline Dosage started at 25 mg a day, with increases up to maximum dosage strength of 200 mg a day.

Duration of treatment was 12 weeks.

Interventions

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Sertraline

Oral Sertraline Dosage started at 25 mg a day, with increases up to maximum dosage strength of 200 mg a day.

Duration of treatment was 12 weeks.

Intervention Type DRUG

Other Intervention Names

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Zoloft

Eligibility Criteria

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Inclusion Criteria

* DSM- IV (Diagnostic and Statistical Manual of Mental Disorders, 4th Edition) diagnostic criteria for major depressive disorder
* Hamilton Depression Scale- 17 item version score of 18 or higher
* Must speak English
* Women must be post-menopausal

Exclusion Criteria

* A current or pervious psychiatric disorder other than MDD
* A current unstable medical condition
* A pacemaker or metal implant
* History of alcohol or drug dependence or abuse within the past year
* Current prescription of excluded medications
* Use of a drug within the last 30 days that was not approved for use by governmental authorities.
* If you or a family member works at McLean Hospital

Minimum Eligible Age

55 Years

Maximum Eligible Age

89 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes