Is There a Relationship Between Hyperlipidemia and Periodontitis?

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

160 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-01-31

Study Completion Date

2016-03-31

Brief Summary

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The aim of present study is to investigate any relationship between hyperlipidemia and periodontal disease regarding the periodontal parameters and plasma lipid parameters, along with age, gender, brushing habit, body mass index, dietary habit, physical activity, alcohol consumption.

In this cross sectional study, a total of 160 individuals were divided into two groups based on their metabolic status: hyperlipidemic group (n=97) and normolipidemic group (n=63). Plaque index, gingival index, bleeding on probing (BOP), probing depth (PD), clinical attachment level (CAL) clinical parameters and community periodontal index of treatment needs (CPITN) scores were measured. Triglyceride (TG), total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C) and high density lipoprotein-cholesterol (HDL-C) levels had been determined previously during individuals routine systemic examinations. Daily brushing habits and interdental cleaning together with dietary habits, alcohol consumption and physical activity levels were also recorded.

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Detailed Description

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Conditions

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Hyperlipidemia, Periodontal Disease

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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HP+

Subjects with plasma Triglyceride or Total cholesterol levels \> 200 mg/dl and low density lipoprotein-cholesterol levels \> 130 mg/dl were included in the hyperlipidemic group and having periodontitis which were further evaluated for clinical periodontal parameters as well as to define the effects of the patient's habits on plasma lipid levels.

No intervention was applied

Intervention Type OTHER

No intervention was applied

HP-

Subjects with plasma Triglyceride or Total cholesterol levels \> 200 mg/dl and low density lipoprotein-cholesterol levels \> 130 mg/dl were included in the hyperlipidemic group and do not have periodontitis which were further evaluated for clinical periodontal parameters as well as to define the effects of the patient's habits on plasma lipid levels.

No intervention was applied

Intervention Type OTHER

No intervention was applied

NP+

Subjects with plasma Triglyceride or Total cholesterol levels \< 200 mg/dl and low density lipoprotein-cholesterol levels \< 130 mg/dl were included in the normolipidemic group and having periodontitis which were further evaluated for clinical periodontal parameters as well as to define the effects of the patient's habits on plasma lipid levels.

No intervention was applied

Intervention Type OTHER

No intervention was applied

NP-

Subjects with plasma Triglyceride or Total cholesterol levels \< 200 mg/dl and low density lipoprotein-cholesterol levels \< 130 mg/dl were included in the normolipidemic group and do not have periodontitis which were further evaluated for clinical periodontal parameters as well as to define the effects of the patient's habits on plasma lipid levels.

No intervention was applied

Intervention Type OTHER

No intervention was applied

Interventions

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No intervention was applied

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Subjects having no periodontal treatment within previous 6 months,
* number of natural teeth ≥ 10,
* no history of cancer and systemic disease that affects lipid levels or periodontium,
* no history of medical treatment for hyperlipidemia, BMI\< 30 kg/m2,
* no pregnancy,
* no history of systemic antibiotic treatment within previous 3 months,
* no smoking.

Exclusion Criteria

* patients with history of systemic disease that affects lipid metabolism or periodontal disease
* history of medical treatment for hyperlipidemia
* pregnancy, lactation or hormone replacement therapy at the time of study
* use of any other drug known to affect lipid metabolism or periodontal disease
* systemic infection or any history of systemic antibiotic treatment in previous 3 months
* smokers as well as ex-smokers

Minimum Eligible Age

35 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No