Dental and Periodontal Health in Obese Adolescents: Clinical, Biochemical, and Microbiological Evaluation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

75 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-06-10

Study Completion Date

2018-08-30

Brief Summary

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This study aims to investigate whether obesity affects oral and gum health in children and adolescents. A total of 75 children aged 8 to 13 years participated, including both obese and non-obese individuals. All participants received a dental examination, and samples of saliva, blood, and gum fluid were collected to measure specific inflammation-related substances (such as IL-1α, IL-1β, and leptin). The presence of specific bacteria in the mouth was also analyzed.

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Detailed Description

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This cross-sectional observational study aimed to investigate the relationship between pediatric obesity and periodontal health by integrating clinical, biochemical, and microbiological assessments. A total of 75 adolescents (36 obese and 39 non-obese), aged 8-13 years, were enrolled. Clinical oral evaluations included dft, DMFT, plaque index (PI), gingival index (GI), and probing depth (PD). Blood, saliva, and gingival crevicular fluid (GCF) samples were collected for ELISA-based measurement of pro-inflammatory biomarkers (IL-1α, IL-1β, and leptin). Subgingival plaque samples were analyzed using real-time PCR to quantify six key periodontal pathogens.

Conditions

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Pediatric Obesity Periodontal Disease Inflammation Biomarkers Dental Plaque Dental Caries

Study Design

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Observational Model Type

OTHER

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Obese Group

Adolescents aged 8-13 years with a body mass index (BMI) above the 95th percentile for age and sex, classified as obese. Participants underwent dental examination and provided saliva, serum, gingival crevicular fluid (GCF), and subgingival plaque samples for biomarker and microbiological analysis.

No interventions assigned to this group

Control Group (Normal Weight)

Adolescents aged 8-13 years with a BMI between the 5th and 85th percentiles for age and sex, considered to have normal weight. The same clinical and sample collection procedures were applied as in the obese group.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

Children aged between 8 and 13 years

Parental consent obtained

No systemic diseases other than obesity

No current medication use

Exclusion Criteria

Use of antibiotics or anti-inflammatory drugs in the past 3 months

History of systemic disease (other than obesity for the obese group)

Undergoing orthodontic treatment

Missing permanent first molars

Uncooperative behavior during examination

Minimum Eligible Age

8 Years

Maximum Eligible Age

13 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes