Genetic Basis of Rosacea

NCT ID: NCT02787616

Last Updated: 2019-09-26

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 306 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2012-04-13
• Study Completion Date: 2018-11-16

Brief Summary

Rosacea is a common disease characterized by inflammation and vascular abnormalities of the facial skin and ocular surface. The exact pathogenesis of papulopustular rosacea is not well understood and current methods to treat this disease are often unsatisfactory. The purpose of this study is to develop gene expression profiles of papulopustular rosacea compared to those of normal skin. The investigators hope to better understand the abnormal gene functions that might contribute to this condition. This understanding may lead to the development of additional and better treatments for rosacea.

Conditions

Rosacea

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Rosacea Group

buccal swab

Intervention Type: GENETIC

cheek swab for DNA sampling

Non-Rosacea Group

buccal swab

Intervention Type: GENETIC

cheek swab for DNA sampling

Interventions

buccal swab

cheek swab for DNA sampling

Intervention Type: GENETIC

Eligibility Criteria

Inclusion Criteria

1. Clinical signs and symptoms of rosacea (papulopustular or erythrotelangiectatic subtypes) present at enrollment as determined by the investigator

2. All four grandparents of European descent

3. Fitzpatrick skin type I or II

4. Age 18 years or older

1. No history of rosacea

2. No clinical signs or symptoms of rosacea

3. No family history of rosacea

4. All four grandparents of European descent

5. Fitzpatrick skin type I or II

6. Age 18 years or older

Exclusion Criteria

1. Unable or unwilling to provide written informed consent

2. Concomitant facial or medical condition that obscures diagnosis of rosacea (such as malar erythema from lupus erythematosus)

3. Acne vulgaris

4. Unable or unwilling to provide peripheral blood sample (a few teaspoons)

5. Inability for investigator to verify rosacea diagnosis on clinical examination due to rosacea treatment(s) leading to complete lack of signs and symptoms (such prior laser treatments, systemic tetracycline usage, etc.)

6. Use of topical prescription medications or procedures to the face within one month of enrollment

7. Women who are pregnant or lactating

Eligibility Criteria for Non-Rosacea Group:

1. Unable or unwilling to provide written informed consent

2. Acne vulgaris

3. Unable or unwilling to provide peripheral blood sample (a few teaspoons)

4. Women who are pregnant or lactating

5. Use of topical prescription medications or procedures to the face within one month of enrollment

6. Skin conditions that might interfere with interpretation of procedure results (at the discretion of the investigator)

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Stanford University

OTHER

Sponsor Role: lead

Responsible Party

Anne Chang

Associate Professor of Dermatology

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Stanford Dermatology

Redwood City, California, United States

Countries

United States

Other Identifiers

R15006

Identifier Type: -

Identifier Source: org_study_id