Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
721 participants
OBSERVATIONAL
2020-05-05
2024-12-15
Brief Summary
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Coronavirus 2019 (COVID-19, or SARS-CoV-2) is a serious public health problem, and genetics may play a role in how serious the illness becomes in certain people. Genes are the instructions that our body uses to grow and develop. Variations in our genes can cause medical conditions and may be the reason why some people get sicker than others.
Objective:
This study aims to learn more about the genetic contributions to the severity of COVID-19. We hope to use this information to develop therapies that reduce the severity of COVID-19 symptoms in some people.
Eligibility:
Anyone located in the United States who has tested positive for SARS-CoV-2 infection may be eligible to join (including NIH staff).
Design:
Participants will complete a questionnaire about their health history and COVID-19 symptoms.
Participants will give a blood or saliva sample. It will be about 2 tablespoons of blood, or we will send a saliva collection kit. Researchers will use this blood or saliva sample to study the participant s DNA.
The data about participants genes will be stored in a large database. The database will be shared with other qualified researchers who are trying to learn about COVID-19. Participants names and other personal details will not be shared. Instead, the data will be labeled with a code.
Participants may be contacted by study team members for up to a year after they join the study.
Detailed Description
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Conditions
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Keywords
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Sample Group 1 (NIHCC)
Existing NIH Clinical Center patients/participants tested positive for SARS-CoV-2 invited to participate by their NIH study team
No interventions assigned to this group
Sample Group 2 (OMS & Field)
Recruited through NIH OMS, referred by collaborators or who self-refer, tested positive for SARS-CoV-2 (and selected relatives of participants irrespective of infection status)
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Cohort 2 (Individuals recruited through NIH Occupational Medicine Services (OMS) patients referred by NIH investigators or other providers; individuals who self-refer)
* Located in the United States
* Positive test for SARS-CoV-2 virus infection
* Age greater than or equal to 3 years old
* only for participants providing a blood sample
Exclusion Criteria
* Weight less than 10 kg\*
1 Month
110 Years
ALL
No
Sponsors
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National Human Genome Research Institute (NHGRI)
NIH
Responsible Party
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Principal Investigators
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Leslie G Biesecker, M.D.
Role: PRINCIPAL_INVESTIGATOR
National Human Genome Research Institute (NHGRI)
Locations
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National Institutes of Health Clinical Center
Bethesda, Maryland, United States
Countries
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Related Links
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NIH Clinical Center Detailed Web Page
Other Identifiers
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200090
Identifier Type: -
Identifier Source: org_study_id
20-HG-0090
Identifier Type: -
Identifier Source: secondary_id