Identification of Mutations Responsible for Rare Familial Skin Diseases by Next Generation Sequencing

NCT ID: NCT02509650

Last Updated: 2016-10-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

25 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-09-30

Study Completion Date

2018-02-28

Brief Summary

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The primary purpose of the protocol is to use next generation sequencing to identify pathogenic variants in genes involved in very rare skin diseases.

The secondary purpose will be to study the genotype-phenotype correlation in order to re-evaluate the classification of these disorders. This work could help in the understanding of the physiopathology of very rare skin disorders.

Detailed Description

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Conditions

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Familial Lipomatosis Very Rare Dermatologic Diseases

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* patients affected by familial lipomatosis
* patients with rare dermatologic disease without molecular diagnosis
* written informed consent is obtained from the patient and his/her family

Exclusion Criteria

* the patient does not want to participate to the protocol
* the patient is already included in another study using next generation sequencing technologies
Minimum Eligible Age

2 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Strasbourg, France

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Salima EL CHEHADEH, MD

Role: PRINCIPAL_INVESTIGATOR

Hôpitaux Universitaires de Strasbourg

Locations

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Fédération de Génétique, Service de Génétique Médicale, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg

Strasbourg, , France

Site Status RECRUITING

Service de Dermatologie, Hôpital Civil, Hôpitaux Universitaires de Strasbourg

Strasbourg, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Salima EL CHEHADEH, MD

Role: CONTACT

33.3.88.12.81.20

Dan LIPSKER, MD

Role: CONTACT

33.3.88.11.61.79

Facility Contacts

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Dan LIPSKER, MD

Role: primary

33.3.88.11.61.79

Salima EL CHEHADEH, MD

Role: primary

33.3.88.12.81.25

Other Identifiers

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6024

Identifier Type: -

Identifier Source: org_study_id

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