Genetic Basis of Melanocytic Nevi

NCT ID: NCT03054584

Last Updated: 2025-09-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-06-26

Study Completion Date

2028-06-30

Brief Summary

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The objective of this protocol is to further elucidate the genetic mutations that drive melanocytic nevi (benign melanocytic neoplasms, moles). This will be performed by whole genome, whole exome, or targeted sequencing of de-identified specimens.

Herein, the investigators plan to isolate DNA from de-identified skin biopsy specimens and blood samples:

1. From melanocytic nevi collected by skin biopsy (a shave or punch biopsy). A part of the tissue will be submitted for routine diagnostic dermatopathology and investigational histomorphologic and immunohistochemical analysis.
2. From corresponding normal tissue (blood). DNA isolated from blood will be used as a normal control when analyzing sequencing data to identify somatic mutations in lesional tissue.

Detailed Description

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Conditions

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Melanocytic Nevi

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Interventions

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Collecting Nevi

Will be collecting Nevi and completing a DNA analysis, no intervention will be made.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Male or female subjects that are 18 years or older
* Subjects with melanocytic nevi\\

Exclusion Criteria

* Patients less than 18 years of age
* Patients without melanocytic nevi
* Patients with a bleeding disorder or are taking anticoagulation medication
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of California, Davis

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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University of California-Davis, Department of Dermatology

Sacramento, California, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Maija Kiuru, MD

Role: CONTACT

916-734-0591

John Robb

Role: CONTACT

916-551-2636

Facility Contacts

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John Robb

Role: primary

916-551-2636

Other Identifiers

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960347

Identifier Type: -

Identifier Source: org_study_id

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