Somatic Mosaicism in Twins Discordant for Childhood Cancer
NCT ID: NCT06054295
Last Updated: 2025-12-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
50 participants
OBSERVATIONAL
2024-06-03
2027-06-30
Brief Summary
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Detailed Description
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I. To conduct a descriptive study of same sex twins (MZ and DZ) discordant for childhood CNS tumors identified through the Children's Oncology Group Project:EveryChild registry.
II. To compare the prevalence of somatic mosaicism in classic cancer-associated genes in monozygotic (MZ) twins discordant for childhood brain tumors. In our pilot study, we will sequence blood and saliva DNA samples from 25 MZ twin pairs using a panel of 94 known cancer associated genes.
SECONDARY OBJECTIVES:
I. To compare the profile of mutations detected in DNA extracted from pre- and post-treatment blood samples from a subset of CNS tumor patients. The purpose of this aim is to ensure that differences in somatic mosaicism detected in twin pairs are not caused by cancer therapy.
Outline:
Twins with CNS tumors will undergo blood and saliva DNA samples with the goal is to learn more about genetic differences that may lead to CNS tumor development.
Conditions
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Study Design
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FAMILY_BASED
PROSPECTIVE
Study Groups
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Ancillary-Correlative
Twins with CNS tumors, identified through the Children's Oncology Group's Project:EveryChild (PEC) registry, will have both blood and saliva samples collected at the time of study enrollment.
Biospecimen collection
Collection of both blood and saliva samples from participants at the time of study enrollment
Questionnaire Administration
The brief questionnaire will assess health history, demographics, environmental exposures, family history of cancer, and birth characteristics.
Interventions
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Biospecimen collection
Collection of both blood and saliva samples from participants at the time of study enrollment
Questionnaire Administration
The brief questionnaire will assess health history, demographics, environmental exposures, family history of cancer, and birth characteristics.
Eligibility Criteria
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Inclusion Criteria
* Patient must have same sex twin. Note: (history of) treatment on a COG therapeutic trial is not required.
* Patients must be diagnosed at \< 19 years of age at the time of diagnosis.
* A family is eligible to participate if the twin with the CNS tumor is deceased but has a blood sample banked through APEC14B1.
* All patients and/or their parents or legal guardians must provide informed consent. Assent will be obtained for participants between the ages of 8-17 years.
* All institutional, FDA, and NCI requirements for human studies must be met.
18 Years
ALL
No
Sponsors
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National Cancer Institute (NCI)
NIH
Children's Oncology Group
NETWORK
Responsible Party
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Principal Investigators
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Jenny Poynter, PhD
Role: STUDY_CHAIR
University of Minnesota
Locations
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University of Minnesota
Minneapolis, Minnesota, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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AEPI22N2
Identifier Type: -
Identifier Source: org_study_id