The Molecular Basis of Inherited Reproductive Disorders
NCT ID: NCT05971836
Last Updated: 2025-07-25
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
600 participants
OBSERVATIONAL
2021-01-21
2026-03-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Subjects with Reproductive Disorders
Individuals with reproductive disorders and their affected and unaffected family members
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Failure to go through a normal, age-appropriate, spontaneous puberty and low sex steroid levels in the setting of low/normal gonadotropins or,
* Abnormally early development of puberty or,
* Normal puberty with subsequent development of low gonadotropin levels or,
* Evidence of a reproductive disorder with high gonadotropin levels or,
* Pre-pubertal individuals with features suggestive of hypogonadotropic hypogonadism or,
* Affected and unaffected family members of individuals that fit criteria above
1 Year
ALL
No
Sponsors
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Stephanie B. Seminara, MD
OTHER
Responsible Party
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Stephanie B. Seminara, MD
Chief, Reproductive Endocrine Unit; Professor of Medicine, Harvard Medical School; Director, MGH Harvard Center for Reproductive Medicine
Principal Investigators
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Stephanie Seminara, MD
Role: PRINCIPAL_INVESTIGATOR
Massachusetts General Hospital
Locations
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Massachusetts General Hospital
Boston, Massachusetts, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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2020P000762
Identifier Type: -
Identifier Source: org_study_id
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